X0202 4/A 2006-08-01 2006-08-03 0 0001095330 SYMYX TECHNOLOGIES INC SMMX 0001216627 GOLDWASSER ISY C/O SYMYX TECHNOGIES, INC. 3100 CENTRAL EXPRESSWAY SANTA CLARA CA 95051 0 1 0 0 President Common Stock 2006-08-01 4 S 0 285 23.53 D 42270 D Common Stock 2006-08-01 4 S 0 430 23.54 D 41840 D Common Stock 2006-08-01 4 S 0 1300 23.56 D 40540 D Common Stock 2006-08-01 4 S 0 500 23.60 D 40040 D Common Stock 2006-08-01 4 S 0 15 23.61 D 40025 D Common Stock 2006-08-01 4 S 0 200 23.68 D 39825 D Common Stock 2006-08-01 4 S 0 500 23.69 D 39325 D Common Stock 2006-08-01 4 S 0 200 23.70 D 39125 D Common Stock 2006-08-01 4 S 0 500 23.71 D 38625 D Common Stock 2006-08-01 4 S 0 700 23.72 D 37925 D Common Stock 2006-08-01 4 S 0 200 23.73 D 37725 D Common Stock 2006-08-01 4 S 0 257 23.83 D 37468 D Common Stock 2006-08-01 4 S 0 613 23.88 D 36855 D Common Stock 2006-08-01 4 S 0 1800 23.92 D 35055 D Common Stock 2006-08-02 4 M 0 10730 0.964 A 45785 D Common Stock 2006-08-02 4 S 0 100 23.66 D 45685 D Common Stock 2006-08-02 4 S 0 1390 23.71 D 44295 D Common Stock 2006-08-02 4 S 0 2000 23.73 D 42295 D Common Stock 2006-08-02 4 S 0 103 23.81 D 42192 D Common Stock 2006-08-02 4 S 0 1200 23.83 D 40992 D Common Stock 2006-08-02 4 S 0 200 23.84 D 40792 D Common Stock 2006-08-02 4 S 0 807 23.88 D 39985 D Common Stock 2006-08-02 4 S 0 501 23.93 D 39484 D Common Stock 2006-08-02 4 S 0 799 23.95 D 38685 D Common Stock 2006-08-02 4 S 0 400 23.96 D 38285 D Stock Option (Right to Buy) 0.964 2006-08-02 4 M 0 10730 0.00 D 2002-02-28 2008-12-04 Common Stock 10730 20381 D The sale reported by this Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on October 25, 2005. Form 4 amended to correct total number of shares disposed. Includes 33,000 restricted stock units payable solely in common stock. Each restricted stock unit represents a contingent right to receive one share of common stock. Isy Goldwasser by Anne Marie Peters, Attorney-In-Fact 2006-08-04