X0303 4 2010-07-01 1 0001095330 SYMYX TECHNOLOGIES INC SMMX 0001216627 GOLDWASSER ISY C/O SYMYX TECHNOLOGIES, INC. 1263 EAST ARQUES AVENUE SUNNYVALE CA 94085 1 1 0 0 Chief Executive Officer Common Stock 2010-07-01 4 D 0 117108 D 0 D Incentive Stock Option (right to buy) 25.50 2010-07-01 4 D 0 8884 D 2011-01-11 Common Stock 8884 0 D Non-Qualified Stock Option (right to buy) 25.00 2010-07-01 4 D 0 80000 D 2011-06-18 Common Stock 80000 0 D Non-Qualified Stock Option (right to buy) 16.70 2010-07-01 4 D 0 50000 D 2012-03-01 Common Stock 50000 0 D Incentive Stock Option (right to buy) 13.26 2010-07-01 4 D 0 9705 D 2013-03-03 Common Stock 9705 0 D Non-Qualified Stock Option (right to buy) 26.70 2010-07-01 4 D 0 12500 D 2014-02-28 Common Stock 12500 0 D Non-Qualified Stock Option (right to buy) 24.09 2010-07-01 4 D 0 12500 D 2014-06-01 Common Stock 12500 0 D Non-Qualified Stock Option (right to buy) 18.95 2010-07-01 4 D 0 12500 D 2014-09-01 Common Stock 12500 0 D Non-Qualified Stock Option (right to buy) 31.53 2010-07-01 4 D 0 12500 D 2014-12-01 Common Stock 12500 0 D Non-Qualified Stock Option (right to buy) 27.89 2010-07-01 4 D 0 50000 D 2015-03-01 Common Stock 50000 0 D Non-Qualified Stock Option (right to buy) 8.58 2010-07-01 4 D 0 200000 D 2012-11-02 Common Stock 200000 0 D Non-Qualified Stock Option (right to buy) 3.69 2010-07-01 4 D 0 200000 D 2015-12-08 Common Stock 200000 0 D Non-Qualified Stock Option (right to buy) 25.50 2010-07-01 4 D 0 41116 D 2011-01-11 Common Stock 41116 0 D Non-Qualified Stock Option (right to buy) 13.26 2010-07-01 4 D 0 140295 D 2013-03-03 Common Stock 140295 0 D Disposed of pursuant to the merger agreement among Symyx Technologies, Inc., Accelrys, Inc. ("Accelrys") and Alto Merger Sub, Inc., dated April 5, 2010, in exchange for 91,367 shares of Accelrys common stock having a market value of $6.66 per share on the effective date of the merger. This option, which is fully vested, was assumed by Accelrys pursuant to the Merger Agreement and converted into an option to purchase 6,931 shares of Accelrys common stock at an exercise price of $32.69 per share. This option, which is fully vested, was assumed by Accelrys pursuant to the Merger Agreement and converted into an option to purchase 62,416 shares of Accelrys common stock at an exercise price of $32.05 per share. This option, which is fully vested, was assumed by Accelrys pursuant to the Merger Agreement and converted into an option to purchase 39,010 shares of Accelrys common stock at an exercise price of $21.41 per share. This option, which is fully vested, was assumed by Accelrys pursuant to the Merger Agreement and converted into an option to purchase 7,571 shares of Accelrys common stock at an exercise price of $17.00 per share. This option, which is fully vested, was assumed by Accelrys pursuant to the Merger Agreement and converted into an option to purchase 9,752 shares of Accelrys common stock at an exercise price of $34.23 per share. This option, which is fully vested, was assumed by Accelrys pursuant to the Merger Agreement and converted into an option to purchase 9,752 shares of Accelrys common stock at an exercise price of $30.88 per share. This option, which is fully vested, was assumed by Accelrys pursuant to the Merger Agreement and converted into an option to purchase 9,752 shares of Accelrys common stock at an exercise price of $24.29 per share. This option, which is fully vested, was assumed by Accelrys pursuant to the Merger Agreement and converted into an option to purchase 9,752 shares of Accelrys common stock at an exercise price of $40.42 per share. This option, which is fully vested, was assumed by Accelrys pursuant to the Merger Agreement and converted into an option to purchase 39,010 shares of Accelrys common stock at an exercise price of $35.75 per share. This option, which provided for vesting in increments of (i) 20% of the option shares on March 1, 2009, (ii) 40% of the option shares on March 1, 2010 and (iii) the remaining 40% of the option shares on March 1, 2011, was assumed by Accelrys pursuant to the Merger Agreement and converted into an option to purchase 156,040 shares of Accelrys common stock at an exercise price of $11.00 per share. This option, which provided for vesting in increments of (i) 16.67% of the option shares on June 8, 2009 and (ii) the remaining balance of the option shares in equal consecutive quarterly installments over the 30-month period thereafter until fully-vested, was assumed by Accelrys pursuant to the Merger Agreement and converted into an option to purchase 156,040 shares of Accelrys common stock at an exercise price of $4.73 per share. This option, which is fully vested, was assumed by Accelrys pursuant to the Merger Agreement and converted into an option to purchase 32,078 shares of Accelrys common stock at an exercise price of $32.69 per share. This option, which is fully vested, was assumed by Accelrys pursuant to the Merger Agreement and converted into an option to purchase 109,458 shares of Accelrys common stock at an exercise price of $17.00 per share. /s/ Rex Jackson, Attorney-In-Fact 2010-07-02