X0609 4 2026-03-06 0 0000886163 LIGAND PHARMACEUTICALS INC LGND 0001216074 LAMATTINA JOHN L false 555 HERITAGE DRIVE SUITE 200 JUPITER FL 33458 1 0 0 0 0 Common Stock 2026-03-06 4 M 0 2161 114.15 A 32885 D Common Stock 2026-03-06 4 S 0 2161 200.76 D 30724 D Non-Qualified Stock Option (right to buy) 114.15 2026-03-06 4 M 0 2161 0 D 2028-06-19 Common Stock 2161 0 D This Option was previously reported as a Grant of 2,474 shares, which vested in full on June 6, 2019, at an exercise price of $195.91 per share, but was adjusted pursuant to the OmniAb Inc. separation from the issuer. By: /s/ Andrew Reardon, Attorney-in-Fact For John L. LaMattina 2026-03-31