X0306 4 2022-11-02 0000097745 THERMO FISHER SCIENTIFIC INC. TMO 0001216055 CASPER MARC N 168 THIRD AVENUE WALTHAM MA 02451 1 1 Chairman & CEO Common Stock 2022-11-03 4 S 0 800 483.13 D 185404.53 D Common Stock 2022-11-03 4 S 0 332 483.99 D 185072.53 D Common Stock 2022-11-03 4 S 0 200 485.46 D 184872.53 D Common Stock 2022-11-03 4 S 0 1976 486.82 D 182896.53 D Common Stock 2022-11-03 4 S 0 2160 487.85 D 180736.53 D Common Stock 2022-11-03 4 S 0 1632 488.97 D 179104.53 D Common Stock 2022-11-03 4 S 0 1000 489.99 D 178104.53 D Common Stock 2022-11-03 4 S 0 100 490.74 D 178004.53 D Common Stock 2000 I By Alison Casper 2020 Irrevocable Trust Common Stock 89155 I By Floral Park Associates, Inc. The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 26, 2021. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $482.52 to $483.48, inclusive. The reporting person undertakes to provide to Thermo Fisher Scientific Inc. ("TMO"), any security holder of TMO or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnotes (2), (3), (4), (5), (6), (7), and (8) to this Form 4. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $483.64 to $484.44, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $485.25 to $485.66, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $486.41 to $487.35, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $487.42 to $488.32, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $488.49 to $489.40, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $489.59 to $490.49, inclusive. The reporting person disclaims beneficial ownership of the securities reported herein as indirectly beneficially owned, except to the extent of any pecuniary interest therein. One of two Form 4's filed on November 4, 2022 for the reporting of transactions occurring on November 2, 2022 and November 3, 2022, both partially included in the first Form 4. The second Form 4 includes additional transactions occurring on November 3, 2022 that could not be included in the first Form 4 due to a limitation on the number of line items that can be included per table in a single Form 4. /s/ Melodie T. Morin, Attorney-in-Fact for Marc N. Casper 2022-11-04