X0303 4 2009-10-01 0000904973 GTC BIOTHERAPEUTICS INC GTCB 0001214939 HEIDEN WILLIAM K C/O GTC BIOTHERAPEUTICS, INC. 175 CROSSING BOULEVARD FRAMINGHAM MA 01702 1 0 0 0 Stock Option (Right to Buy) 1.52 2009-10-01 4 A 0 3000 0 A 2019-10-01 Common Stock 3000 3000 D Granted pursuant to Issuer's 2002 Equity Incentive Plan, as amended and restated. 1,500 shares became fully exercisable on the grant date and the remaining 1,500 shares will become fully exercisable on the date of the Issuer's 2010 annual meeting. /s/ Nathaniel S. Gardiner as attorney-in-fact for William K. Heiden 2009-10-05