X0306 4 2016-08-05 0001472091 Edge Therapeutics, Inc. EDGE 0001214501 MIDDLEKAUFF W BRADFORD 200 CONNELL DRIVE SUITE 1600 BERKELEY HEIGHTS NJ 07922 1 Senior VP, GC and Secretary Common Stock 2016-08-05 4 P 0 9857 9.48 A 9857 D Common Stock 2016-08-08 4 P 0 143 9.43 A 10000 D The reported price in Column 4 is a weighted average purchase price. These shares were purchased in multiple transactions at prices ranging from $9.42 to $9.60 per share. The Reporting Person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. /s/ W. Bradford Middlekauff, Reporting Person 2016-08-09