144 0001213895 XXXXXXXX LIVE 0001802768 Royalty Pharma plc 001-39329 110 East 59th Street New York NY 10022 212-883-0200 Errol B. De Souza Former Affiliate Class A ordinary shares J.P. Morgan Securities LLC 270 Park Avenue, 10th Floor New York NY 10017 206352 11925082 445277344 08/12/2026 NASDAQ Class A ordinary shares 08/07/2026 Conversion of LP Interests See "Remark"s section below N 125000 08/07/2026 N/A Class A ordinary shares 05/13/2026 Compensation Issuer N 7614 05/13/2026 N/A Class A ordinary shares 05/12/2025 Compensation Issuer N 9293 05/12/2025 N/A Class A ordinary shares 06/06/2024 Compensation Issuer N 7747 06/06/2024 N/A Class A ordinary shares 06/30/2023 Compensation Issuer N 6328 06/30/2023 N/A Class A ordinary shares 06/30/2022 Compensation Issuer N 5726 06/30/2022 N/A Class A ordinary shares 06/30/2021 Compensation Issuer N 44644 06/30/2021 N/A Y Of the shares filed today, 125,000 shares were acquired from Errol Bento De Souza, who transferred the LP Interests originally received on 06/16/20 from the Issuer, to the Revocable Trust on 01/12/22. The shares covered by this filing will be sold by the Errol Bento De Souza Revocable Trust. 08/12/2026 /s/ J.P. Morgan Securities LLC as agent and attorney-in-fact for Errol B. De Souza