Note 1 - Organization and Summary of Significant Accounting Policies - Research and Development Costs (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Outside contracted services	$ 748,139	$ 1,616,605	$ 1,391,186	$ 2,752,161
Personnel related costs	147,414	199,475	299,608	406,265
Facilities, overhead and other	21,999	14,718	37,324	15,234
Research And Development Expense, Including Related Party	$ 917,552	$ 1,830,798	$ 1,728,118	$ 3,173,660