Note 1 - Organization and Summary of Significant Accounting Policies (Details Textual)	1 Months Ended	3 Months Ended		9 Months Ended	12 Months Ended
	Jan. 31, 2023 USD ($)	Mar. 31, 2023 USD ($) shares	Mar. 31, 2022 USD ($) shares	Sep. 30, 2022	Dec. 31, 2022 USD ($)	Dec. 31, 2021
Number of Operating Segments		1
Revenue from Contract with Customer, Excluding Assessed Tax		$ 978,052	$ 648,427
Accounts Receivable, Allowance for Credit Loss, Ending Balance		0			$ 0
Deferred Tax Assets, Net		$ 16,900,000			$ 15,500,000
Deferred Tax Assets, Valuation Allowance Coverage, Percent		100.00%			100.00%
Other Income		$ 989,000	$ 250,000
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount (in shares) | shares		5,581,991	5,425,040
Restricted Stock Units (RSUs) [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount (in shares) | shares		163,044
Share-Based Payment Arrangement, Option [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount (in shares) | shares		5,418,947
Customer Concentration Risk [Member] | Revenue Benchmark [Member]
Concentration Risk, Number of Customers		7	8
Concentration Risk, Significant Customers		3		6
Customer Concentration Risk [Member] | Revenue Benchmark [Member] | Non-US [Member]
Concentration Risk, Number of Customers		1	3
Revenue from Contract with Customer, Excluding Assessed Tax		$ 154,288	$ 136,000
Concentration Risk, Percentage		16.50%	25.50%
Customer Concentration Risk [Member] | Revenue Benchmark [Member] | Three Significant Customers [Member]
Revenue from Contract with Customer, Excluding Assessed Tax		$ 626,000
Concentration Risk, Percentage		67.00%
Customer Concentration Risk [Member] | Revenue Benchmark [Member] | Six Significant Customers [Member]
Revenue from Contract with Customer, Excluding Assessed Tax			$ 512,000
Concentration Risk, Percentage			95.90%
Customer Concentration Risk [Member] | Accounts Receivable [Member]
Concentration Risk, Number of Customers		7			6
Customer Concentration Risk [Member] | Accounts Receivable [Member] | Non-US [Member]
Concentration Risk, Number of Customers		3			4
Concentration Risk, Percentage		13.30%			27.40%
Accounts Receivable, after Allowance for Credit Loss		$ 100,000			$ 91,000
Customer Concentration Risk [Member] | Accounts Receivable [Member] | Three Customers [Member]
Concentration Risk, Percentage		78.10%			88.20%
Accounts Receivable, after Allowance for Credit Loss		$ 588,000			$ 291,000
Supplier Concentration Risk [Member] | Contract Research Organizations [Member]
Concentration Risk, Number of Suppliers				3		2
Supplier Concentration Risk [Member] | Contract Research Organizations [Member] | Three CROs [Member]
Concentration Risk, Percentage		95.00%
Research Services Purchased		$ 1,076,000
Supplier Concentration Risk [Member] | Contract Research Organizations [Member] | Two CROs [Member]
Concentration Risk, Percentage			96.70%
Research Services Purchased			$ 1,494,000
Supplier Concentration Risk [Member] | Accounts Payable [Member]
Concentration Risk, Number of Suppliers		3			3
Supplier Concentration Risk [Member] | Accounts Payable [Member] | Three CROs [Member]
Concentration Risk, Percentage		73.60%			79.70%
Accounts Payable		$ 567,000			$ 1,018,000
Alphazyme [Member]
Proceeds from Sale, Maturity and Collection of Investments	$ 1,270,000	$ 1,270,000