Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Cash flows from operating activities
Net loss	$ (2,491,665)	$ (3,294,949)
Adjustments to reconcile net loss to net cash used in operating activities:
Stock-based compensation expense	453,791	421,071
Amortization of held-to-maturity securities, net	13,446	63,951
Foreign currency exchange loss (gain), net	(10,247)	28,272
Changes in operating assets and liabilities:
Interest receivable	65,481	(44,954)
Accounts receivable	(241,002)	(131,800)
Prepaid expenses and other current assets	131,299	64,297
Accounts payable	(679,918)	480,455
Accrued expenses	(176,396)	(212,088)
Deferred research and development obligation	163,859	719,232
Deferred license revenue	(79,031)	0
Net cash used in operating activities	(2,850,383)	(1,906,513)
Cash flows from investing activities
Purchases of held-to-maturity investment securities	(5,020,850)	(11,283,940)
Proceeds from maturities of investment securities	4,500,000	5,500,000
Net cash used in investing activities	(520,850)	(5,783,940)
Cash flows from financing activities
Proceeds from exercise of options	42,350	115,800
Net cash provided by financing activities	42,350	115,800
Effect of exchange rate changes on cash	(568)	(6,834)
Net decrease in cash and cash equivalents	(3,329,451)	(7,581,487)
Cash and cash equivalents at beginning of period	15,748,480	20,637,045
Cash and cash equivalents at end of period	$ 12,419,029	$ 13,055,558