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Note 3 - Research and Collaboration Agreements, Sublicense Agreements, and Investments in Privately Held Companies (Details Textual) € in Millions				1 Months Ended		3 Months Ended		12 Months Ended
	Jun. 24, 2020	Jun. 30, 2017 USD ($)	Jun. 30, 2017 EUR (€)	Apr. 30, 2022 USD ($)	Aug. 31, 2021 USD ($)	Mar. 31, 2022 USD ($)	Mar. 31, 2021 USD ($)	Dec. 31, 2021 USD ($)	Feb. 10, 2022	Dec. 16, 2021 USD ($)	Dec. 16, 2021 EUR (€)	Jul. 26, 2021	Jul. 08, 2021 shares	Dec. 01, 2020 USD ($)	Apr. 26, 2019
Revenue from Contract with Customer, Excluding Assessed Tax						$ 648,427,000	$ 460,520,000
Number of Performance Obligations										2	2
Upfront Payment Payable										$ 500,000
Research and Development Expense, Related Party								$ 0
Deferred License Revenue, Current						112,146,000		147,059,000
Deferred License Revenue, Net of Current Portion						308,823,000		352,941,000
Cost of Goods and Services Sold, Total						404,746,000	390,762,000
Accounts Receivable, after Allowance for Credit Loss, Current, Total						528,151,000		$ 277,831,000
Collaborative Arrangement, Payment for Research and Development Agreement		$ 1,100,000	€ 1.0
Research and Development Expense, Total						1,342,862,000	1,808,098,000
BDI Holdings [Member]
Proceeds from Sales of Business, Affiliate and Productive Assets					$ 1,600,000
Research Services Agreement [Member]
Collaborative Arrangement, Payment for Research and Development Agreement \| €			€ 1.0
Alphazyme [Member]
Sale of Stock, Percentage of Ownership after Transaction	2.50%
Novovet [Member]
Equity Method Investment, Ownership Percentage															20.00%
ID Biologics Inc [Member]
Investment Owned, Balance, Shares (in shares) \| shares													129,661
Noncontrolling Interest, Ownership Percentage by Noncontrolling Owners													0.37%
Cost of Goods and Services Sold, Total						109,000
Accounts Receivable, after Allowance for Credit Loss, Current, Total						156,000
Alphazyme [Member]
Ownership Percentage														1.99%
Equity Securities without Readily Determinable Fair Value, Amount														$ 284,709
BDI Holdings [Member]
Ownership Percentage												16.10%
Research and Development Expense, Total						0
Equity Method Investment, Ownership Percentage															20.00%
BDI Holdings [Member] \| Research Services Agreement [Member]
Collaborative Arrangement, Equity Interest Acquired		16.10%	16.10%
Collaborative Arrangement, Minimum Obligation For Research and Development		$ 936,000
VLPBio Member
Ownership Percentage												3.30%
VLPBio Member \| Research Services Agreement [Member]
Collaborative Arrangement, Equity Interest Acquired		3.30%	3.30%
Abic Biolgical Latories Ltd. [Member]
Number of Performance Obligations									2
Janssen Pharmaceutical Companies [Member]
Non-refundable Upfront Payment, Received										$ 500,000
Deferred License Revenue, Current						112,146
Deferred License Revenue, Net of Current Portion						308,823
Deferred License Revenue						14,706
License [Member]
Revenue from Contract with Customer, Excluding Assessed Tax						114,706,000	0
License [Member] \| Abic Biolgical Latories Ltd. [Member]
Revenue from Contract with Customer, Excluding Assessed Tax						100,000
License [Member] \| Abic Biolgical Latories Ltd. [Member] \| Subsequent Event [Member]
Revenue from Contract with Customer, Excluding Assessed Tax				$ 100,000
Research and Development [Member]
Revenue from Contract with Customer, Excluding Assessed Tax						$ 533,721,000	$ 460,520,000
Research and Development [Member] \| Janssen Pharmaceutical Companies [Member]
Contract with Customer, Asset, after Allowance for Credit Loss, Total \| €											€ 1.6