Note 1 - Organization and Summary of Significant Accounting Policies - Research and Development Costs (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Outside contracted services	$ 1,135,556	$ 1,659,194
Personnel related costs	206,790	148,162
Facilities, overhead and other	516	742
Research And Development Expense, Including Related Party	$ 1,342,862	$ 1,808,098