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Note 1 - Organization and Summary of Significant Accounting Policies - Accrued Expenses (Details) - USD ($)
$ in Thousands
Mar. 31, 2022
Jan. 01, 2022
Dec. 31, 2021
Research and development expenses   $ 257,000 $ 194,250
Employee wages and benefits   200,257 405,758
Other   75,750 109,552
Accrued Liabilities, Current, Total $ 533,007 $ 533,007 $ 709,560