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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
9 Months Ended
Sep. 30, 2020
Sep. 30, 2019
Cash flows from operating activities    
Net loss $ (7,365,060) $ (6,569,434)
Adjustments to reconcile net loss to net cash used in operating activities:    
Stock-based compensation expense 1,264,233 1,034,346
Amortization of held-to-maturity securities, net 282,123 141,362
Foreign currency exchange loss (gain), net 26,317 24,693
Changes in operating assets and liabilities:    
Interest receivable 223,306 58,800
Accounts receivable (141,698) (110,807)
Income tax receivable 500,616 497,460
Prepaid research and development 0 253,446
Prepaid expenses and other current assets (141,550) (164,590)
Accounts payable (61,651) 429,955
Accrued expenses 50,745 70,541
Deferred research and development obligation 75,211 (47,726)
Net cash used in operating activities (5,287,408) (4,381,954)
Cash flows from investing activities    
Purchases of held-to-maturity investment securities (14,677,156) (37,585,548)
Proceeds from maturities of investment securities 36,761,000 43,953,000
Net cash provided by investing activities 22,083,844 6,367,452
Cash flows from financing activities    
Proceeds from exercise of options 230,810 328,590
Net cash provided by financing activities 230,810 328,590
Effect of exchange rate changes on cash 11,791 (38,075)
Net increase in cash and cash equivalents 17,039,037 2,276,013
Cash and cash equivalents at beginning of period 4,823,544 2,386,314
Cash and cash equivalents at end of period 21,862,581 4,662,327
Supplemental cash flow information    
Cash received from income tax refund $ 500,616 $ 506,866