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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
3 Months Ended
Mar. 31, 2020
Mar. 31, 2019
Cash flows from operating activities    
Net loss $ (2,214,139) $ (2,175,258)
Adjustments to reconcile net loss to net cash used in operating activities:    
Stock-based compensation expense 426,939 309,563
Amortization of held-to-maturity securities, net 107,256 32,201
Foreign currency exchange loss (gain), net 10,867 5,148
Changes in operating assets and liabilities:    
Interest receivable 102,565 3,981
Accounts receivable 35,258 (106,781)
Income tax receivable 0 6,249
Prepaid research and development 0 83,112
Prepaid expenses and other current assets (10,529) 5,049
Accounts payable (292,361) 641,799
Accrued expenses (326,000) (96,606)
Deferred research and development obligation 163,799 (117,978)
Net cash used in operating activities (1,996,345) (1,409,521)
Cash flows from investing activities    
Purchases of held-to-maturity investment securities (11,652,385) (13,190,855)
Proceeds from maturities of investment securities 13,350,000 16,197,000
Net cash provided by investing activities 1,697,615 3,006,145
Cash flows from financing activities    
Proceeds from exercise of options 175,000 0
Net cash provided by financing activities 175,000 0
Effect of exchange rate changes on cash (2,983) (7,177)
Net (decrease) increase in cash and cash equivalents (126,713) 1,589,447
Cash and cash equivalents at beginning of period 4,823,544 2,386,314
Cash and cash equivalents at end of period 4,696,831 3,975,761
Supplemental cash flow information    
Cash received from income tax refund $ 0 $ 6,249