Commitments and Contingencies - Collaborative Arrangement (Details) - USD ($)	3 Months Ended
	Mar. 31, 2017	Mar. 31, 2016
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Restructuring charges	$ 1,719,804	$ 0
Boreal | Research and Development Expense
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Professional and Contract Services Expense	33,000
Impaired Long-Lived Assets
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Restructuring charges	$ 500,000