May 9, 2019

Thomas H. Adams
Chief Executive Officer
Trovagene, Inc.
11055 Flintkote Avenue
San Diego, CA 92121

       Re: Trovagene, Inc.
           Post-Effective Amendment to Form S-1
           Filed April 25, 2019
           File No. 333-224808

Dear Mr. Adams:

       We have reviewed your post-effective amendment and have the following
comment.

       Please respond to this letter by amending your registration statement
and providing the
requested information. If you do not believe our comment applies to your facts
and
circumstances or do not believe an amendment is appropriate, please tell us why
in your
response.

       After reviewing any amendment to your registration statement and the
information you
provide in response to this comment, we may have additional comments.

Post -Effective Amendment No. 1 to Form S-1

General

1.     We note that this post-effective amendment seeks to update the
prospectuses included in
       the Form S-1 (333-224808) initially filed on May 10, 2018, and the Form
S-1 (333-
       225510) filed June 8, 2018 in which you registered a primary offering of
Class A units,
       Class B units, and Common Stock issuable upon the exercise of warrants.
Since the initial
       filings did not register a resale offering, it is inappropriate to add a
resale offering by
       means of a post-effective amendment. Please amend your filing to remove
the resale
       offering.
        We remind you that the company and its management are responsible for
the accuracy
and adequacy of their disclosures, notwithstanding any review, comments, action
or absence of
action by the staff.
 Thomas H. Adams
Trovagene, Inc.
May 9, 2019
Page 2

       You may contact Jeffrey Gabor at 202-551-2544 or Mary Beth Breslin at
202-551-3625
with any questions.



                                                        Sincerely,
FirstName LastNameThomas H. Adams
                                                        Division of Corporation
Finance
Comapany NameTrovagene, Inc.
                                                        Office of Healthcare &
Insurance
May 9, 2019 Page 2
cc:       Jeffrey Fessler, Esq.
FirstName LastName