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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 HclI8znuWoKKSJUGjStUvVibZ4k/9WX80pq/tVcVosYk99eu9wOYhR2YzvXiF/my
 JCa+OX34E44mM8dwKfLOmw==

<SEC-DOCUMENT>0001181431-03-018839.txt : 20030814
<SEC-HEADER>0001181431-03-018839.hdr.sgml : 20030814
<ACCEPTANCE-DATETIME>20030814213006
ACCESSION NUMBER:		0001181431-03-018839
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20030812
FILED AS OF DATE:		20030814

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			GREER R SCOTT
		CENTRAL INDEX KEY:			0001211703

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-27914
		FILM NUMBER:		03849374

	MAIL ADDRESS:	
		STREET 1:		6701 KAISER DRIVE
		CITY:			FREMONT
		STATE:			CA
		ZIP:			94555

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			SIRNA THERAPEUTICS INC
		CENTRAL INDEX KEY:			0000892112
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				341697351
		STATE OF INCORPORATION:			CO
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		2950 WILDERNESS PLACE
		CITY:			BOULDER
		STATE:			CO
		ZIP:			80301
		BUSINESS PHONE:		3034496500

	MAIL ADDRESS:	
		STREET 1:		2950 WILDERNESS PLACE
		CITY:			BOULDER
		STATE:			CO
		ZIP:			80301

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	RIBOZYME PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	19960306
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>rrd16114.xml
<DESCRIPTION>FORM 4
<TEXT>
<XML>
<?xml version="1.0"?><ownershipDocument>
    <schemaVersion>X0201</schemaVersion>

    <documentType>4</documentType><periodOfReport>2003-08-12</periodOfReport><notSubjectToSection16>0</notSubjectToSection16>
    <issuer>
        <issuerCik>0000892112</issuerCik>
        <issuerName>SIRNA THERAPEUTICS INC</issuerName>
        <issuerTradingSymbol>RNAI</issuerTradingSymbol></issuer><reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001211703</rptOwnerCik>
            <rptOwnerName>GREER R SCOTT</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>2950 WILDERNESS PLACE</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>BOULDER</rptOwnerCity>
            <rptOwnerState>CO</rptOwnerState>
            <rptOwnerZipCode>80301</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
            <reportingOwnerRelationship>
<isDirector>1</isDirector><isOfficer>0</isOfficer><isTenPercentOwner>0</isTenPercentOwner><isOther>0</isOther></reportingOwnerRelationship></reportingOwner><nonDerivativeTable><nonDerivativeTransaction><securityTitle><value>Common Stock</value></securityTitle><transactionDate><value>2003-08-12</value></transactionDate><deemedExecutionDate><value>2003-08-12</value></deemedExecutionDate><transactionCoding><transactionFormType>4</transactionFormType><transactionCode>M</transactionCode><equitySwapInvolved>0</equitySwapInvolved></transactionCoding><transactionAmounts><transactionShares><value>50000</value><footnoteId id="F2"/></transactionShares><transactionPricePerShare><value>3.41</value></transactionPricePerShare><transactionAcquiredDisposedCode><value>A</value></transactionAcquiredDisposedCode></transactionAmounts><postTransactionAmounts><sharesOwnedFollowingTransaction><value>55000</value></sharesOwnedFollowingTransaction></postTransactionAmounts><ownershipNature><directOrIndirectOwnership><value>D</value></
directOrIndirectOwnership></ownershipNature></nonDerivativeTransaction></nonDerivativeTable><derivativeTable><derivativeTransaction><securityTitle><value>Non Qualified Stock Option</value></securityTitle><conversionOrExercisePrice><value>4.26</value></conversionOrExercisePrice><transactionDate><value>2003-08-12</value></transactionDate><transactionCoding><transactionFormType>4</transactionFormType><transactionCode>A</transactionCode><equitySwapInvolved>0</equitySwapInvolved></transactionCoding><transactionAmounts><transactionShares><value>75000</value></transactionShares><transactionPricePerShare><value>0.00</value></transactionPricePerShare><transactionAcquiredDisposedCode><value>A</value></transactionAcquiredDisposedCode></transactionAmounts><exerciseDate><footnoteId id="F1"/></exerciseDate><expirationDate><value>2013-08-12</value></expirationDate><underlyingSecurity><underlyingSecurityTitle><value>Common Stock</value></underlyingSecurityTitle><underlyingSecurityShares><value>75000</value></underlyingSecur
ityShares></underlyingSecurity><postTransactionAmounts><sharesOwnedFollowingTransaction><value>75000</value></sharesOwnedFollowingTransaction></postTransactionAmounts><ownershipNature><directOrIndirectOwnership><value>D</value></directOrIndirectOwnership></ownershipNature></derivativeTransaction><derivativeTransaction><securityTitle><value>Non Qualified Stock Option</value></securityTitle><conversionOrExercisePrice><value>3.41</value></conversionOrExercisePrice><transactionDate><value>2003-08-12</value></transactionDate><transactionCoding><transactionFormType>4</transactionFormType><transactionCode>A</transactionCode><equitySwapInvolved>0</equitySwapInvolved></transactionCoding><transactionAmounts><transactionShares><value>50000</value></transactionShares><transactionPricePerShare><value>0.00</value></transactionPricePerShare><transactionAcquiredDisposedCode><value>A</value></transactionAcquiredDisposedCode></transactionAmounts><exerciseDate><footnoteId id="F2"/></exerciseDate><expirationDate><value>2013-08-
12</value></expirationDate><underlyingSecurity><underlyingSecurityTitle><value>Common Stock</value></underlyingSecurityTitle><underlyingSecurityShares><value>50000</value></underlyingSecurityShares></underlyingSecurity><postTransactionAmounts><sharesOwnedFollowingTransaction><value>50000</value></sharesOwnedFollowingTransaction></postTransactionAmounts><ownershipNature><directOrIndirectOwnership><value>D</value></directOrIndirectOwnership></ownershipNature></derivativeTransaction><derivativeTransaction><securityTitle><value>Non Qualified Stock Option</value></securityTitle><conversionOrExercisePrice><value>3.41</value></conversionOrExercisePrice><transactionDate><value>2003-08-12</value></transactionDate><transactionCoding><transactionFormType>4</transactionFormType><transactionCode>M</transactionCode><equitySwapInvolved>0</equitySwapInvolved></transactionCoding><transactionAmounts><transactionShares><value>50000</value></transactionShares><transactionPricePerShare><value>0.00</value></transactionPricePerSha
re><transactionAcquiredDisposedCode><value>D</value></transactionAcquiredDisposedCode></transactionAmounts><exerciseDate><footnoteId id="F2"/></exerciseDate><expirationDate><value>2013-08-12</value></expirationDate><underlyingSecurity><underlyingSecurityTitle><value>Common Stock</value></underlyingSecurityTitle><underlyingSecurityShares><value>50000</value></underlyingSecurityShares></underlyingSecurity><postTransactionAmounts><sharesOwnedFollowingTransaction><value>0</value></sharesOwnedFollowingTransaction></postTransactionAmounts><ownershipNature><directOrIndirectOwnership><value>D</value></directOrIndirectOwnership></ownershipNature></derivativeTransaction></derivativeTable><footnotes><footnote id="F1">Non qualified stock option granted under the terms of the issuers 2001 Stock Option Plan.  The option vests as follows: 6,252 shares are immediately vested and exercisable and the remaining shares vest in a series of 33 equal monthly installments beginning on August 21, 2003.</footnote><footnote id="F2">No
n Qualified stock option granted under the terms of the issuers 2001 Stock Option Plan. The option vests as follows: 40,000 shares are immediately vested and exercisable and the remaining shares vest in a series of 36 equal monthly installments beginning on September 12, 2003 (the "Unvested Shares"). With respect to the Unvested Shares, such shares were exercised prior to full vesting and therefore Mr. Greer received restricted shares, subject to vesting, which may be repurchased by the issuer if Mr. Greer ceases to be Chairman of the Audit Committee prior to full vesting of such shares. The Unvested Shares are subject to becoming fully vested upon change of control of the issuer or Mr. Greer's death or disability.</footnote></footnotes><ownerSignature><signatureName>R. Scott Greer</signatureName><signatureDate>2003-08-14</signatureDate></ownerSignature></ownershipDocument>



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