X0303 4 2010-04-30 0 0001211583 ADHEREX TECHNOLOGIES INC AHX 0001319998 Southpoint Capital Advisors LP 623 FIFTH AVENUE SUITE 2601 NEW YORK NY 10022 0 0 1 0 0001378377 Southpoint Capital Advisors LLC 623 FIFTH AVENUE, SUITE 2601 NEW YORK NY 10022 0 0 1 0 0001378376 Southpoint GP, LP 623 FIFTH AVENUE, SUITE 2601 NEW YORK NY 10022 0 0 1 0 0001378378 Southpoint GP, LLC 623 FIFTH AVENUE, SUITE 2601 NEW YORK NY 10022 0 0 1 0 0001378379 Clark John Smith II 623 FIFTH AVENUE, SUITE 2601 NEW YORK NY 10022 0 0 1 0 Common Stock 2010-04-30 4 P 0 200000000 A 241504000 I See Footnotes Common Stock Warrants (right to buy) 0.08 2010-04-30 4 P 0 200000000 A 2010-10-30 2015-04-30 Common Stock 200000000 200000000 I See Footnotes The reported securities are included within 200,000,000 units purchased by the reporting persons for CDN$0.03 per unit. Each unit consists of one share of common stock of Adherex Technologies Inc., and one warrant to purchase one share of common stock of Adherex Technologies Inc. Southpoint Capital Advisors LP, and its general partner Southpoint Capital Advisors LLC, hold the reported securities indirectly on behalf of Southpoint Fund LP, Southpoint Qualified Fund LP, Southpoint Master Fund, LP and Southpoint Offshore Fund, Ltd., for which Southpoint Capital Advisors LP serves as investment manager. Southpoint GP, LP, and its general partner Southpoint GP, LLC, hold the reported securities indirectly on behalf of Southpoint Fund LP, Southpoint Qualified Fund LP, and Southpoint Master Fund, LP, of which Southpoint GP, LP is the general partner. John S. Clark II reports the securities held indirectly by Southpoint GP, LLC and Southpoint Capital Advisors LLC as the manager of each. Each of the reporting persons disclaims beneficial ownership of the reported securities except to the extent of his or its pecuniary interest therein, and this report shall not be deemed an admission that such reporting person is the beneficial owner of the securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose. The exercise price of the warrants reported is listed in Canadian Dollars. SOUTHPOINT CAPITAL ADVISORS LP, By: Southpoint Capital Advisors LLC, its General Partner, By: John S. Clark II, Managing Member 2010-05-07 SOUTHPOINT CAPITAL ADVISORS LLC, By: John S. Clark, II, Managing Member 2010-05-07 SOUTHPOINT GP, LP, By: Southpoint GP, LLC, its General Partner, By: John S. Clark, II, Managing Member 2010-05-07 SOUTHPOINT GP, LLC, By: John S. Clark, II, Managing Member 2010-05-07 John S. Clark, II 2010-05-07