X0305 4 2012-06-01 0 0001012140 ONYX PHARMACEUTICALS INC ONXX 0001209721 OSBORN JOHN E C/O ONYX PHARMACEUTICALS, INC. 249 EAST GRAND AVE. SOUTH SAN FRANCISCO CA 94080 0 1 0 0 SVP, Global Corporate Affairs Common Stock 2012-06-01 4 A 0 11000 0.00 A 11000 D Stock Option (Right to Buy) 44.93 2012-06-01 4 A 0 87360 0.00 A 2022-05-31 Common Stock 87360 87360 D Represents restricted stock units granted to the reporting person. Each restricted stock unit represents a right to receive one share of the issuer's common stock. The restricted stock unit vests upon the meeting of certain milestones. Twenty-Five percent of the shares subject to the option vest and become exercisable one year from the date of grant. The remaining shares become exercisable in equal monthly installments over the following 36 months for a total vesting schedule of 48 months. /s/ Matthew K. Fust, Attorney-in-fact 2012-06-01