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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
6 Months Ended
Jun. 30, 2018
Jun. 30, 2017
Cash flows from operating activities:    
Net loss $ (9,101) $ (8,689)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 461 171
Amortization of debt discount 347 977
Accretion of the April 2017 convertible note conversion premium 0 280
Liquidated damages 1,112 998
Share-based compensation 122 165
Loss on impairment of intangible assets 653 0
Gain on extinguishment of debt (181) 0
Issuance of common stock to consultant 38 0
Change in fair value of derivative instrument (38) 0
Disposal of equipment 0 267
Accretion of redemption premium on November 2016 convertible note 0 300
Changes in operating assets and liabilities:    
Other assets 25 301
Accounts payable 28 908
Accrued expenses and advances from related parties (315) (131)
Net cash used in operating activities (6,849) (4,453)
Cash flows from investing activities:    
Change in restricted cash 0 59
Purchase of property and equipment (61) (22)
Net cash (used in) provided by in investing activities (61) 37
Cash flows from financing activities:    
Proceeds from May 2018 Convertible Notes 2,007 0
Payment of dividends on Series E Preferred Stock (160) 0
Repayment of Mablife Notes Payable (205) 0
Proceeds received from November 2016 and March 2017 Equity Line financings 0 5,383
Financing fees paid on November 2016 and March 2017 Equity Line financing 0 (118)
Payment of commitment fees related to March 2017 Equity Line financing 0 (1,010)
Proceeds from amending certain securities purchase agreements 0 238
Repayment of capital lease 0 (24)
Repayment of November 2016 Convertible Notes 0 (1,350)
Proceeds from April 2017 Convertible Notes 0 440
Repayment of April 2017 Convertible Notes 0 (97)
Proceeds from May 2017 Convertible Notes 0 1,579
Repayment of senior secured term loan payable 0 (874)
Net cash provided by financing activities 1,642 4,167
Decrease in cash (5,268) (249)
Cash at beginning of period 6,776 271
Cash at end of period 1,508 22
Supplemental disclosure of cash flow information:    
Cash paid for interest 0 160
Supplemental disclosure of non-cash financing activities:    
Warrants issued in connection with May 2018 Convertible Notes 91 0
Common stock issued to settle liabilities 0 14
Acquisition of Ceplene Rights 0 4,218
Conversion of April 2017 Convertible Notes prepayment into May 2017 Convertible Notes $ 0 $ 154