Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014
Revenue	$ 0	$ 2
Costs and expenses:
Research and development	5,935	5,640
General and administrative	9,789	10,725
Total costs and expenses	15,724	16,365
Loss from operations	(15,724)	(16,363)
Non-operating expense:
Interest expense	(827)	(3,404)
Derivative liability instrument expense	(128)	(558)
Warrant amendment expense	0	(3,145)
Loss on extinguishment of debt	(463)	0
Other expense, net	(15)	(80)
Total non-operating expense:	(1,433)	(7,187)
Net loss before income taxes	(17,157)	(23,550)
Net loss	(17,157)	(23,550)
Deemed dividend	(6,959)	(616)
Series C Preferred Stock dividend	0	(256)
Loss attributable to common stockholders	$ (24,116)	$ (24,422)
Basic and diluted loss per common share	$ (0.90)	$ (1.46)
Weighted average common shares outstanding - basic and diluted	26,741,392	16,742,550
Comprehensive loss	$ (17,157)	$ (23,550)