<?xml version="1.0" encoding="UTF-8"?><own:edgarSubmission xmlns:own="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <!-- Generated by Workiva -->
  <own:headerData>
    <own:submissionType>144/A</own:submissionType>
    <own:previousAccessionNumber>0001628280-26-047461</own:previousAccessionNumber>
    <own:filerInfo>
      <own:filer>
        <own:filerCredentials>
          <own:cik>0001207790</own:cik>
          <own:ccc>XXXXXXXX</own:ccc>
        </own:filerCredentials>
      </own:filer>
      <own:liveTestFlag>LIVE</own:liveTestFlag>



    </own:filerInfo>
  </own:headerData>
  <own:formData>
    <own:issuerInfo>
      <own:issuerCik>0001645469</own:issuerCik>
      <own:issuerName>Monopar Therapeutics Inc.</own:issuerName>
      <own:issuerAddress>
        <com:street1>1000 Skokie Blvd</com:street1>
        <com:street2>Suite 350</com:street2>
        <com:city>Wilmette</com:city>
        <com:stateOrCountry>IL</com:stateOrCountry>
        <com:zipCode>60091</com:zipCode>
      </own:issuerAddress>
      <own:issuerContactPhone>847-388-0349</own:issuerContactPhone>
      <own:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Arthur Klausner</own:nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <own:relationshipsToIssuer>
        <own:relationshipToIssuer>Former Board Member</own:relationshipToIssuer>
      </own:relationshipsToIssuer>
    </own:issuerInfo>
    <own:securitiesInformation>
      <own:securitiesClassTitle>Common Stock</own:securitiesClassTitle>
      <own:brokerOrMarketmakerDetails>
        <own:name>MLPFS</own:name>
        <own:address>
          <com:street1>One Bryant Park 40th fl</com:street1>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10036</com:zipCode>
        </own:address>
      </own:brokerOrMarketmakerDetails>
      <own:noOfUnitsSold>5000</own:noOfUnitsSold>
      <own:aggregateMarketValue>476967</own:aggregateMarketValue>
      <own:noOfUnitsOutstanding>0</own:noOfUnitsOutstanding>
      <own:approxSaleDate>07/08/2026</own:approxSaleDate>
      <own:securitiesExchangeName>NASDAQ</own:securitiesExchangeName>
    </own:securitiesInformation>
    <own:securitiesToBeSold>
      <own:securitiesClassTitle>Common Stock</own:securitiesClassTitle>
      <own:acquiredDate>12/31/2023</own:acquiredDate>
      <own:natureOfAcquisitionTransaction>Restricted Stock Unit Vesting</own:natureOfAcquisitionTransaction>
      <own:nameOfPersonfromWhomAcquired>Arthur Klausner</own:nameOfPersonfromWhomAcquired>
      <own:isGiftTransaction>N</own:isGiftTransaction>
      <own:amountOfSecuritiesAcquired>506</own:amountOfSecuritiesAcquired>
      <own:paymentDate>07/08/2026</own:paymentDate>
      <own:natureOfPayment>Granted as part of issuer equity compensation plan.</own:natureOfPayment>
    </own:securitiesToBeSold>
    <own:securitiesToBeSold>
      <own:securitiesClassTitle>Common Stock</own:securitiesClassTitle>
      <own:acquiredDate>09/30/2023</own:acquiredDate>
      <own:natureOfAcquisitionTransaction>Restricted Stock Unit Vesting</own:natureOfAcquisitionTransaction>
      <own:nameOfPersonfromWhomAcquired>Arthur Klausner</own:nameOfPersonfromWhomAcquired>
      <own:isGiftTransaction>N</own:isGiftTransaction>
      <own:amountOfSecuritiesAcquired>507</own:amountOfSecuritiesAcquired>
      <own:paymentDate>07/08/2026</own:paymentDate>
      <own:natureOfPayment>Granted as part of issuer equity compensation plan.</own:natureOfPayment>
    </own:securitiesToBeSold>
    <own:securitiesToBeSold>
      <own:securitiesClassTitle>Common Stock</own:securitiesClassTitle>
      <own:acquiredDate>06/30/2023</own:acquiredDate>
      <own:natureOfAcquisitionTransaction>Restricted Stock Unit Vesting</own:natureOfAcquisitionTransaction>
      <own:nameOfPersonfromWhomAcquired>Arthur Klausner</own:nameOfPersonfromWhomAcquired>
      <own:isGiftTransaction>N</own:isGiftTransaction>
      <own:amountOfSecuritiesAcquired>507</own:amountOfSecuritiesAcquired>
      <own:paymentDate>07/08/2026</own:paymentDate>
      <own:natureOfPayment>Granted as part of issuer equity compensation plan.</own:natureOfPayment>
    </own:securitiesToBeSold>
    <own:securitiesToBeSold>
      <own:securitiesClassTitle>Common Stock</own:securitiesClassTitle>
      <own:acquiredDate>03/31/2023</own:acquiredDate>
      <own:natureOfAcquisitionTransaction>Restricted Stock Unit Vesting</own:natureOfAcquisitionTransaction>
      <own:nameOfPersonfromWhomAcquired>Arthur Klausner</own:nameOfPersonfromWhomAcquired>
      <own:isGiftTransaction>N</own:isGiftTransaction>
      <own:amountOfSecuritiesAcquired>507</own:amountOfSecuritiesAcquired>
      <own:paymentDate>07/08/2026</own:paymentDate>
      <own:natureOfPayment>Granted as part of issuer equity compensation plan.</own:natureOfPayment>
    </own:securitiesToBeSold>
    <own:securitiesToBeSold>
      <own:securitiesClassTitle>Common Stock</own:securitiesClassTitle>
      <own:acquiredDate>12/31/2022</own:acquiredDate>
      <own:natureOfAcquisitionTransaction>Restricted Stock Unit Vesting</own:natureOfAcquisitionTransaction>
      <own:nameOfPersonfromWhomAcquired>Arthur Klausner</own:nameOfPersonfromWhomAcquired>
      <own:isGiftTransaction>N</own:isGiftTransaction>
      <own:amountOfSecuritiesAcquired>571</own:amountOfSecuritiesAcquired>
      <own:paymentDate>07/08/2026</own:paymentDate>
      <own:natureOfPayment>Granted as part of issuer equity compensation plan.</own:natureOfPayment>
    </own:securitiesToBeSold>
    <own:securitiesToBeSold>
      <own:securitiesClassTitle>Common Stock</own:securitiesClassTitle>
      <own:acquiredDate>09/30/2022</own:acquiredDate>
      <own:natureOfAcquisitionTransaction>Restricted Stock unit vesting</own:natureOfAcquisitionTransaction>
      <own:nameOfPersonfromWhomAcquired>Arthur Klausner</own:nameOfPersonfromWhomAcquired>
      <own:isGiftTransaction>N</own:isGiftTransaction>
      <own:amountOfSecuritiesAcquired>572</own:amountOfSecuritiesAcquired>
      <own:paymentDate>07/08/2026</own:paymentDate>
      <own:natureOfPayment>Granted as part of issuer equity compensation plan.</own:natureOfPayment>
    </own:securitiesToBeSold>
    <own:securitiesToBeSold>
      <own:securitiesClassTitle>Common Stock</own:securitiesClassTitle>
      <own:acquiredDate>06/30/2022</own:acquiredDate>
      <own:natureOfAcquisitionTransaction>Restricted stock unit vesting</own:natureOfAcquisitionTransaction>
      <own:nameOfPersonfromWhomAcquired>Arthur Klausner</own:nameOfPersonfromWhomAcquired>
      <own:isGiftTransaction>N</own:isGiftTransaction>
      <own:amountOfSecuritiesAcquired>572</own:amountOfSecuritiesAcquired>
      <own:paymentDate>07/08/2026</own:paymentDate>
      <own:natureOfPayment>Granted as part of issuer equity compensation plan</own:natureOfPayment>
    </own:securitiesToBeSold>
    <own:securitiesToBeSold>
      <own:securitiesClassTitle>Common Stock</own:securitiesClassTitle>
      <own:acquiredDate>03/31/2022</own:acquiredDate>
      <own:natureOfAcquisitionTransaction>Restricted stock unit vesting</own:natureOfAcquisitionTransaction>
      <own:nameOfPersonfromWhomAcquired>Arthur Klausner</own:nameOfPersonfromWhomAcquired>
      <own:isGiftTransaction>N</own:isGiftTransaction>
      <own:amountOfSecuritiesAcquired>572</own:amountOfSecuritiesAcquired>
      <own:paymentDate>07/08/2026</own:paymentDate>
      <own:natureOfPayment>Granted as part of issuer equity compensation plan</own:natureOfPayment>
    </own:securitiesToBeSold>
    <own:securitiesToBeSold>
      <own:securitiesClassTitle>Common Stock</own:securitiesClassTitle>
      <own:acquiredDate>03/31/2021</own:acquiredDate>
      <own:natureOfAcquisitionTransaction>Restricted stock unit vesting</own:natureOfAcquisitionTransaction>
      <own:nameOfPersonfromWhomAcquired>Arthur Klausner</own:nameOfPersonfromWhomAcquired>
      <own:isGiftTransaction>N</own:isGiftTransaction>
      <own:amountOfSecuritiesAcquired>150</own:amountOfSecuritiesAcquired>
      <own:paymentDate>07/08/2026</own:paymentDate>
      <own:natureOfPayment>Granted as part of issuer equity compensation plan</own:natureOfPayment>
    </own:securitiesToBeSold>
    <own:securitiesToBeSold>
      <own:securitiesClassTitle>Common Stock</own:securitiesClassTitle>
      <own:acquiredDate>06/30/2021</own:acquiredDate>
      <own:natureOfAcquisitionTransaction>Restricted stock unit vesting</own:natureOfAcquisitionTransaction>
      <own:nameOfPersonfromWhomAcquired>Arthur Klausner</own:nameOfPersonfromWhomAcquired>
      <own:isGiftTransaction>N</own:isGiftTransaction>
      <own:amountOfSecuritiesAcquired>150</own:amountOfSecuritiesAcquired>
      <own:paymentDate>07/08/2026</own:paymentDate>
      <own:natureOfPayment>Granted as part of issuer equity compensation plan</own:natureOfPayment>
    </own:securitiesToBeSold>
    <own:securitiesToBeSold>
      <own:securitiesClassTitle>Common Stock</own:securitiesClassTitle>
      <own:acquiredDate>09/30/2021</own:acquiredDate>
      <own:natureOfAcquisitionTransaction>Restricted stock unit vesting</own:natureOfAcquisitionTransaction>
      <own:nameOfPersonfromWhomAcquired>Arthur Klausner</own:nameOfPersonfromWhomAcquired>
      <own:isGiftTransaction>N</own:isGiftTransaction>
      <own:amountOfSecuritiesAcquired>150</own:amountOfSecuritiesAcquired>
      <own:paymentDate>07/08/2026</own:paymentDate>
      <own:natureOfPayment>Granted as part of issuer equity compensation plan</own:natureOfPayment>
    </own:securitiesToBeSold>
    <own:securitiesToBeSold>
      <own:securitiesClassTitle>Common Stock</own:securitiesClassTitle>
      <own:acquiredDate>12/31/2021</own:acquiredDate>
      <own:natureOfAcquisitionTransaction>Restricted stock unit vesting</own:natureOfAcquisitionTransaction>
      <own:nameOfPersonfromWhomAcquired>Arthur Klausner</own:nameOfPersonfromWhomAcquired>
      <own:isGiftTransaction>N</own:isGiftTransaction>
      <own:amountOfSecuritiesAcquired>151</own:amountOfSecuritiesAcquired>
      <own:paymentDate>07/08/2026</own:paymentDate>
      <own:natureOfPayment>Granted as part of issuer equity compensation plan</own:natureOfPayment>
    </own:securitiesToBeSold>
    <own:securitiesToBeSold>
      <own:securitiesClassTitle>Common Stock</own:securitiesClassTitle>
      <own:acquiredDate>09/30/2020</own:acquiredDate>
      <own:natureOfAcquisitionTransaction>Restricted stock unit vesting</own:natureOfAcquisitionTransaction>
      <own:nameOfPersonfromWhomAcquired>Arthur Klausner</own:nameOfPersonfromWhomAcquired>
      <own:isGiftTransaction>N</own:isGiftTransaction>
      <own:amountOfSecuritiesAcquired>21</own:amountOfSecuritiesAcquired>
      <own:paymentDate>07/08/2026</own:paymentDate>
      <own:natureOfPayment>Granted as part of issuer equity compensation plan</own:natureOfPayment>
    </own:securitiesToBeSold>
    <own:securitiesToBeSold>
      <own:securitiesClassTitle>Common Stock</own:securitiesClassTitle>
      <own:acquiredDate>12/31/2020</own:acquiredDate>
      <own:natureOfAcquisitionTransaction>Restricted stock unit vesting</own:natureOfAcquisitionTransaction>
      <own:nameOfPersonfromWhomAcquired>Arthur Klausner</own:nameOfPersonfromWhomAcquired>
      <own:isGiftTransaction>N</own:isGiftTransaction>
      <own:amountOfSecuritiesAcquired>64</own:amountOfSecuritiesAcquired>
      <own:paymentDate>07/08/2026</own:paymentDate>
      <own:natureOfPayment>Granted as part of issuer equity compensation plan</own:natureOfPayment>
    </own:securitiesToBeSold>
    <own:nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</own:nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <own:noticeSignature>
      <own:noticeDate>07/10/2026</own:noticeDate>
      <own:signature>Arthur Klausner</own:signature>
    </own:noticeSignature>
  </own:formData>
</own:edgarSubmission>
