X0202 4 2007-06-13 0000729922 OSI PHARMACEUTICALS INC OSIP 0001206369 KLEIN JOSEPH III C/O OSI PHARMACEUTICALS, INC. 41 PINELAWN ROAD MELVILLE NY 11747 1 Common Stock 2007-06-13 4 A 0 1500 0 A 13000 D Stock Option (Right to Buy) 36.25 2007-06-13 4 A 0 3000 0 A 2008-06-13 2014-06-12 Common Stock 3000 3000 D Represents the formula grant of Deferred Stock Units to the director upon re-election to the Board of Directors of OSI Pharmaceuticals, Inc. 25% of the Deferred Stock Units vest one year after the date of grant and the remainder will vest ratably on an annual basis over the succeeding 3 years. Mr. Klein will receive one share of OSI Common Stock for each vested Deferred Stock Unit that he holds upon the termination of his service on OSI Pharmaceuticals, Inc.'s Board of Directors 25% of the option will become exerciseable one year after the date of grant and the remainder will vest ratably on an annual basis over the succeeding 3 years. /s/ Michael G. Atieh, attorney-in-fact for Mr. Klein 2007-06-15