X0508 4 2023-08-03 0 0001888886 Structure Therapeutics Inc. GPCR 0001206199 WELCH DANIEL G C/O STRUCTURE THERAPEUTICS INC. 611 GATEWAY BLVD., SUITE 223 SOUTH SAN FRANCISCO CA 94080 1 0 0 0 0 Stock option (right to buy) 2.60 2023-08-03 4 J 0 411000 7.97 D 2032-01-19 Ordinary Shares 411000 768122 D Stock option (right to buy) 2.60 2023-08-03 4 J 0 205500 7.97 A 2032-01-19 Ordinary Shares 205500 205500 I By Trust Stock option (right to buy) 2.60 2023-08-03 4 J 0 205500 7.97 A 2032-01-19 Ordinary Shares 205500 205500 I By Trust The reported transactions involve the Reporting Person's transfer of the vested portion of his option to trusts established for the benefit of his children. The transfer was a substitution for minority interests in a family limited partnership of equivalent value previously gifted to the trusts. The price per share is 1/3 of the closing price of the Issuer's American Depositary Shares ("ADS") on the date of transfer less the exercise price per share of the option. Each ADS consist of three of the Issuer's ordinary shares. 1/3rd of the shares vested one year after January 5, 2022 (the "Vesting Commencement Date"); the balance of the shares vest in a series of 24 successive equal monthly installments measured from the first anniversary of the Vesting Commencement Date. The option is held by the Andrew J. Welch 2020 Irrevocable GST Trust, dated July 1, 2020. The Reporting Person is trustee of such trust and his son is the sole beneficiary of such trust. The option is held by the Michael D. Welch 2020 Irrevocable GST Trust, dated July 1, 2020. The Reporting Person is trustee of such trust and his son and such son's descendants are the sole beneficiaries of such trust. /s/ Jun Yoon, Attorney-in-Fact 2023-08-04