X0508 4 2023-12-26 0001205922 VACCINEX, INC. VCNX 0001748247 Van Strydonck, Gerald E. C/O VACCINEX, INC. 1895 MOUNT HOPE AVENUE ROCHESTER NY 14620 1 0 0 0 0 Common Stock 2023-12-26 4 S 0 3149 0.72 D 0 D Stock Option (Right to Buy) 204.0 2027-09-15 Common Stock 426 426 D Stock Option (Right to Buy) 78.9 2029-03-30 Common Stock 166 166 D Stock Option (Right to Buy) 116.7 2020-05-15 Common Stock 514 514 D Stock Option (Right to Buy) 82.8 2029-06-29 Common Stock 159 159 D Stock Option (Right to Buy) 107.55 2029-09-27 Common Stock 123 123 D Stock Option (Right to Buy) 72.75 2029-12-28 Common Stock 182 182 D Stock Option (Right to Buy) 59.25 2021-05-14 Common Stock 1045 1045 D Stock Option (Right to Buy) 32.25 2022-05-11 Common Stock 1905 1905 D Stock Option (Right to Buy) 16.8 2023-05-12 Common Stock 3550 3550 D Stock Option (Right to Buy) 6.15 2024-05-11 Common Stock 9589 9589 D Exercisable in full as of the date of this report. This option expires on May 14, 2029 or five years following retirement or cessation of services, whichever occurs first. This option expires on May 12, 2030 or five years following retirement or cessation of services, whichever occurs first. This option expires on May 9, 2031 or five years following retirement or cessation of services, whichever occurs first. This option expires on May 9, 2032 or five years following retirement or cessation of services, whichever occurs first. This option expires on May 8, 2033 or five years following retirement or cessation of services, whichever occurs first. /s/ Scott E. Royer, Attorney-in-Fact for Gerald Van Strydonck 2023-12-28