X0306 4 2022-05-12 0001205922 VACCINEX, INC. VCNX 0000941871 MANIAN BALA S C/O VACCINEX, INC. 1895 MOUNT HOPE AVENUE ROCHESTER NY 14620 1 0 0 0 Stock Option (Right to Buy) 7.78 2020-05-15 Common Stock 7718 7718 D Stock Option (Right to Buy) 3.95 2021-05-14 Common Stock 15679 15679 D Stock Option (Right to Buy) 2.15 2022-05-11 Common Stock 28586 28586 D Stock Option (Right to Buy) 1.12 2022-05-12 4 A 0 53254 0 A 2023-05-12 Common Stock 53254 53254 D This option expires on May 14, 2029 or five years following retirement or cessation of services, whichever occurs first. This option expires on May 12, 2030 or five years following retirement or cessation of services, whichever occurs first. This option expires on May 9, 2031 or five years following retirement or cessation of services, whichever occurs first. This option was granted pursuant to the Company's 2018 Omnibus Incentive Plan in a transaction exempt under Rule 16b-3 and expires on May 9, 2032 or five years following retirement or cessation of services, whichever occurs first. /s/ Scott E. Royer, Attorney-in-Fact for Bala S. Manian 2022-05-13