X0306 4 2022-04-01 0001205922 VACCINEX, INC. VCNX 0001747769 Smith Ernest S. C/O VACCINEX, INC. 1895 MOUNT HOPE AVENUE ROCHESTER NY 14620 0 1 0 0 SVP, Research & CSO Common Stock 8000 D Stock Option (Right to Buy) 7.10 2025-12-22 Common Stock 40729 40729 D Stock Option (Right to Buy) 7.10 2025-12-23 Common Stock 5110 5110 D Stock Option (Right to Buy) 3.90 2029-03-14 Common Stock 8000 8000 D Stock Option (Right to Buy) 6.07 2030-02-24 Common Stock 8000 8000 D Stock Option (Right to Buy) 2.93 2031-04-02 Common Stock 10000 10000 D Stock Option (Right to Buy) 1.29 2022-04-01 4 A 0 20000 0 A 2032-04-01 Common Stock 20000 20000 D Exercisable in full as of the date of this report. This option was granted under the Company's 2018 Omnibus Incentive Plan in a transaction exempt under Rule 16b-3 and, except as otherwise provided in the award notice, vests one-fourth on each of the first four anniversaries of the March 15, 2019 grant date. This option was granted under the Company's 2018 Omnibus Incentive Plan in a transaction exempt under Rule 16b-3 and, except as otherwise provided in the award notice, vests one-fourth on each of the first four anniversaries of the February 25, 2020 grant date. This option was granted under the Company's 2018 Omnibus Incentive Plan in a transaction exempt under Rule 16b-3 and, except as otherwise provided in the award notice, vests one-fourth on each of the first four anniversaries of the April 2, 2021 grant date. This option was granted under the Company's 2018 Omnibus Incentive Plan in a transaction exempt under Rule 16b-3 and, except as otherwise provided in the award notice, vests one-fourth on each of the first four anniversaries of the April 1, 2022 grant date. /s/ Scott E. Royer, Attorney-in-Fact for Ernest S. Smith 2022-04-04