X0306 4 2022-01-27 0001205922 VACCINEX, INC. VCNX 0001747753 Zauderer Maurice C/O VACCINEX, INC. 1895 MOUNT HOPE AVENUE ROCHESTER NY 14620 1 1 0 0 President and CEO Common Stock 177748 D Common Stock 213209 I By Jeremy C. Zauderer Trust Common Stock 212161 I By Jordan M. Zauderer Trust Common Stock 2022-01-27 4 P 0 1801801 1.11 A 2899554 I By Vaccinex (Rochester), L.L.C. Stock Option (Right to Buy) 14.90 2024-03-31 Common Stock 2589 2589 D Stock Option (Right to Buy) 14.90 2024-06-30 Common Stock 2589 2589 D Stock Option (Right to Buy) 7.10 2025-12-23 Common Stock 3325 3325 D Stock Option (Right to Buy) 4.29 2024-03-14 Common Stock 20000 20000 D Stock Option (Right to Buy) 6.68 2025-02-24 Common Stock 28400 28400 D Stock Option (Right to Buy) 2.93 2031-04-02 Common Stock 14000 14000 D Dr. Zauderer exercises voting control over shares held by this trust and disclaims beneficial ownership over these shares except to the extent of his pecuniary interest therein. Dr. Zauderer is the president and a majority owner of Vaccinex (Rochester), L.L.C. and disclaims beneficial ownership of these shares except to the extent of his pecuniary interest therein. Exercisable in full as of the date of this report. This option was granted under the Company's 2018 Omnibus Incentive Plan in a transaction exempt under Rule 16b-3 and, except as otherwise provided in the award notice, vests one-fourth on each of the first four anniversaries of the March 15, 2019 grant date. This option was granted under the Company's 2018 Omnibus Incentive Plan in a transaction exempt under Rule 16b-3 and, except as otherwise provided in the award notice, vests one-fourth on each of the first four anniversaries of the February 25, 2020 grant date. This option was granted under the Company's 2018 Omnibus Incentive Plan in a transaction exempt under Rule 16b-3 and, except as otherwise provided in the award notice, vests one-fourth on each of the first four anniversaries of the April 2, 2021 grant date. /s/ Scott E. Royer, Attorney-in-Fact for Maurice Zauderer 2022-01-31