X0306 4 2020-02-03 0 0001505512 Regulus Therapeutics Inc. RGLS 0001205903 RASTETTER WILLIAM H C/O REGULUS THERAPEUTICS INC. 10628 SCIENCE CENTER DR., #225 SAN DIEGO CA 92121 1 0 0 0 Common Stock 2020-02-03 4 C 0 225940 A 390584 I The Rastetter Family Trust dtd 9-2-2010 Class A-2 Convertible Preferred Stock 2020-02-03 4 C 0 22594 0.00 D Common Stock 225940 0 I The Rastetter Family Trust dtd 9-2-2010 The shares of Class A-2 Convertible Preferred have no expiration date and are convertible at any time at the election of the holder into shares of Common Stock without payment of further consideration. Each share of Class A-2 Convertible Preferred Stock converts into 10 shares of Common Stock. Christopher Aker, Attorney in Fact 2020-02-04