-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 PKfJA26qD7UwVDbgt5V30r5GZLZ47/ytjzxhIEV5nMWmayQtmRvbM8O29TFhAz3f
 4FQFt1X7PwErmy+vUgCG0Q==

<SEC-DOCUMENT>0001181431-08-027753.txt : 20080501
<SEC-HEADER>0001181431-08-027753.hdr.sgml : 20080501
<ACCEPTANCE-DATETIME>20080501103626
ACCESSION NUMBER:		0001181431-08-027753
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20080422
FILED AS OF DATE:		20080501
DATE AS OF CHANGE:		20080501

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			InfuSystem Holdings, Inc
		CENTRAL INDEX KEY:			0001337013
		STANDARD INDUSTRIAL CLASSIFICATION:	SURGICAL & MEDICAL INSTRUMENTS & APPARATUS [3841]
		IRS NUMBER:				203341405
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		1551 EAST LINCOLN AVENUE, SUITE 200
		CITY:			MADISON HEIGHTS
		STATE:			MI
		ZIP:			48071
		BUSINESS PHONE:		(248) 546-7047

	MAIL ADDRESS:	
		STREET 1:		1551 EAST LINCOLN AVENUE, SUITE 200
		CITY:			MADISON HEIGHTS
		STATE:			MI
		ZIP:			48071

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	HAPC, Inc.
		DATE OF NAME CHANGE:	20060425

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Healthcare Acquisition Partners Corp.
		DATE OF NAME CHANGE:	20050824

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			DREYER DAVID C
		CENTRAL INDEX KEY:			0001203607

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-51902
		FILM NUMBER:		08792864

	MAIL ADDRESS:	
		STREET 1:		C/O SICOR INC
		STREET 2:		19 HUGHES
		CITY:			IRVINE
		STATE:			CA
		ZIP:			92618-1902
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>rrd203931.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2008-04-22</periodOfReport>

    <noSecuritiesOwned>1</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001337013</issuerCik>
        <issuerName>InfuSystem Holdings, Inc</issuerName>
        <issuerTradingSymbol>INHI.OB</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001203607</rptOwnerCik>
            <rptOwnerName>DREYER DAVID C</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O INFUSYSTEM HOLDINGS, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>1551 EAST LINCOLN AVENUE, SUITE 200</rptOwnerStreet2>
            <rptOwnerCity>MADISON HEIGHTS</rptOwnerCity>
            <rptOwnerState>MI</rptOwnerState>
            <rptOwnerZipCode>48071</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <remarks>No securities beneficially owned.</remarks>

    <ownerSignature>
        <signatureName>/s/ David C. Dreyer</signatureName>
        <signatureDate>2008-04-28</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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