X0202 4 2006-03-30 0 0000939767 EXELIXIS INC EXEL 0001202102 SCANGOS GEORGE A C/O EXELIXIS INC. 170 HARBOR WAY, PO BOX 0511 SAN FRANCISCO CA 94083-0511 1 1 0 0 President & CEO Common Stock 2006-03-30 5 G 0 E 1980 0 D 1468111 D Common stock 2006-03-30 5 G 0 E 1980 0 A 6855 I By Trust Common Stock 2006-03-30 5 G 0 E 1980 0 D 1466131 D Common Stock 2006-03-30 5 G 0 E 1980 0 A 6855 I By Trust Common Stock 2816 I By 401(k) Plan 90,909 shares were transferred on 03/30/2006 to the George Scangos & Leslie Wilson Community Property Account from the Leslie Wilson GRAT. The 90,909 shares previously held by the Leslie Wilson GRAT have been reported as part of Dr. Scangos' direct holdings commencing 05/28/03. Excludes a total of 9,750 shares held by George A. Scangos and Leslie S. Wilson, as Trustees of the Katherine Scangos Trust and the Jennifer Scangos Trust, that were previously reported as part of Dr. Scangos' direct holdings commencing 05/28/03. Includes 4,875 shares held by George A. Scangos and Leslie S. Wilson, as Trustees of the Katherine Scangos Trust, that were previously reported as part of Dr. Scangos? direct holdings commencing 05/28/2003. Shares held by George A. Scangos and Leslie S. Wilson, as Trustees of the Katherine Scangos Trust. Includes 4,875 shares held by George A. Scangos and Leslie S. Wilson, as Trustees of the Jennifer Scangos Trust, that were previously reported as part of Dr. Scangos? direct holdings commencing 05/28/2003. Shares held by George A. Scangos and Leslie S. Wilson, as Trustees of the Jennifer Scangos Trust. Represents shares in the Exelixis stock fund based on a plan statement dated 03/28/2006. /s/ George A. Scangos 2006-04-03