X0202 4 2005-12-06 0 0000939767 EXELIXIS INC EXEL 0001202102 SCANGOS GEORGE A C/O EXELIXIS INC. 170 HARBOR WAY, PO BOX 0511 SAN FRANCISCO CA 94083-0511 1 1 0 0 President & CEO Common Stock 2005-12-06 4 S 0 215 8.2647 D 1522126 D Common Stock 2005-12-06 4 S 0 100 8.39 D 1522026 D Common Stock 2005-12-06 4 S 0 100 8.3 D 1521926 D Common Stock 2005-12-06 4 S 0 200 8.28 D 1521726 D Common Stock 2005-12-06 4 S 0 100 8.75 D 1521626 D Common Stock 2005-12-06 4 S 0 100 8.73 D 1521526 D Common Stock 2005-12-06 4 S 0 100 8.64 D 1521426 D Common Stock 2005-12-06 4 S 0 100 8.63 D 1521326 D Common Stock 2005-12-06 4 S 0 200 8.47 D 1521126 D Common Stock 2005-12-06 4 S 0 200 8.49 D 1520926 D Common Stock 2005-12-06 4 S 0 200 8.51 D 1520726 D Common Stock 2005-12-06 4 S 0 200 8.48 D 1520526 D Common Stock 2005-12-06 4 S 0 100 8.46 D 1520426 D Common Stock 2005-12-06 4 S 0 100 8.48 D 1520326 D Common Stock 2005-12-06 4 S 0 85 8.49 D 1520241 D Common Stock 2005-12-06 4 S 0 100 8.37 D 1520141 D Common Stock 2005-12-06 4 S 0 100 8.67 D 1520041 D Common Stock 2005-12-06 4 S 0 200 8.425 D 1519841 D The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 7, 2005. /s/ George Scangos 2005-12-07