X0202 4 2005-11-28 0 0000939767 EXELIXIS INC EXEL 0001202102 SCANGOS GEORGE A C/O EXELIXIS INC. 170 HARBOR WAY, PO BOX 0511 SAN FRANCISCO CA 94083-0511 1 1 0 0 President & CEO COMMON STOCK 2005-11-28 4 S 0 200 7.98 D 1524641 D COMMON STOCK 2005-11-28 4 S 0 100 7.94 D 1524541 D COMMON STOCK 2005-11-28 4 S 0 200 7.96 D 1524341 D COMMON STOCK 2005-11-28 4 S 0 142 7.95 D 1524199 D COMMON STOCK 2005-11-28 4 S 0 100 7.98 D 1524099 D COMMON STOCK 2005-11-28 4 S 0 300 8.25 D 1523799 D COMMON STOCK 2005-11-28 4 S 0 200 8.28 D 1523599 D COMMON STOCK 2005-11-28 4 S 0 100 8.23 D 1523499 D COMMON STOCK 2005-11-28 4 S 0 100 8.21 D 1523399 D COMMON STOCK 2005-11-28 4 S 0 100 8.14 D 1523299 D COMMON STOCK 2005-11-28 4 S 0 100 8.15 D 1523199 D COMMON STOCK 2005-11-28 4 S 0 100 8.11 D 1523099 D COMMON STOCK 2005-11-28 4 S 0 100 8.02 D 1522999 D COMMON STOCK 2005-11-28 4 S 0 200 8.02 D 1522799 D COMMON STOCK 2005-11-28 4 S 0 100 8.01 D 1522699 D COMMON STOCK 2005-11-28 4 S 0 58 8.12 D 1522641 D COMMON STOCK 2005-11-28 4 S 0 100 8.31 D 1522541 D COMMON STOCK 2005-11-28 4 S 0 200 8.00 D 1522341 D The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 7, 2005. /s/ George Scangos 2005-11-29