X0202 4 2005-11-22 0 0000939767 EXELIXIS INC EXEL 0001202102 SCANGOS GEORGE A C/O EXELIXIS INC. 170 HARBOR WAY, PO BOX 0511 SAN FRANCISCO CA 94083-0511 1 1 0 0 President & CEO Common Stock 2005-11-22 4 S 0 100 8.62 D 1527241 D Common Stock 2005-11-22 4 S 0 100 8.62 D 1527141 D Common Stock 2005-11-22 4 S 0 200 8.69 D 1526941 D Common Stock 2005-11-22 4 S 0 200 8.70 D 1526741 D Common Stock 2005-11-22 4 S 0 100 8.68 D 1526641 D Common Stock 2005-11-22 4 S 0 200 8.5 D 1526441 D Common Stock 2005-11-22 4 S 0 100 8.52 D 1526341 D Common Stock 2005-11-22 4 S 0 200 8.51 D 1526141 D Common Stock 2005-11-22 4 S 0 100 8.49 D 1526041 D Common Stock 2005-11-22 4 S 0 300 8.51 D 1525741 D Common Stock 2005-11-22 4 S 0 100 8.52 D 1525641 D Common Stock 2005-11-22 4 S 0 255 8.49 D 1525386 D Common Stock 2005-11-22 4 S 0 100 8.54 D 1525286 D Common Stock 2005-11-22 4 S 0 100 8.55 D 1525186 D Common Stock 2005-11-22 4 S 0 195 8.5 D 1524991 D Common Stock 2005-11-22 4 S 0 100 8.66 D 1524891 D Common Stock 2005-11-22 4 S 0 50 8.52 D 1524841 D The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on September 7, 2005. /s/ George Scangos 2005-11-23