X0306 4 2018-06-01 0 0001505512 Regulus Therapeutics Inc. RGLS 0001202098 PAPADOPOULOS STELIOS C/O REGULUS THERAPEUTICS INC. 10614 SCIENCE CENTER DRIVE SAN DIEGO CA 92121 1 0 0 0 Stock Option (Right to Buy) 0.73 2018-06-01 4 A 0 55000 0.00 A 2028-05-31 Common Stock 55000 55000 D The option will vest in twelve equally monthly installments, such that the option will be fully vested one year from the date of grant, or the date of the Company's 2019 annual shareholder meeting, whichever occurs first. Christopher Aker, Attorney in Fact 2018-06-05