-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
 MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen
 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 IJKprJwWo30b+WBsj4aRPkIk5cLn7cQf2YWYAJyL/iP08m3o3MZLwnq5dPQQkpb7
 xgruzQ5Aq8MF5y0shWIVYw==

<SEC-DOCUMENT>0000898432-07-001014.txt : 20071205
<SEC-HEADER>0000898432-07-001014.hdr.sgml : 20071205
<ACCEPTANCE-DATETIME>20071205175045
ACCESSION NUMBER:		0000898432-07-001014
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20071128
FILED AS OF DATE:		20071205
DATE AS OF CHANGE:		20071205

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Ardea Biosciences, Inc./DE
		CENTRAL INDEX KEY:			0001103390
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				943200380
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		2131 PALOMAR ROAD
		STREET 2:		SUITE 300
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92011
		BUSINESS PHONE:		760-602-8422

	MAIL ADDRESS:	
		STREET 1:		2131 PALOMAR ROAD
		STREET 2:		SUITE 300
		CITY:			CARLSBAD
		STATE:			CA
		ZIP:			92011

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	INTRABIOTICS PHARMACEUTICALS INC /DE
		DATE OF NAME CHANGE:	20000127

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			ANDREEFF DANE
		CENTRAL INDEX KEY:			0001201810

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-33734
		FILM NUMBER:		071287584

	BUSINESS ADDRESS:	
		STREET 1:		C/O ANDREEFF EQUITY ADVISORS LLC
		STREET 2:		450 LAUREL STREET STE 2105
		CITY:			BATON ROUGE
		STATE:			LA
		ZIP:			70801
		BUSINESS PHONE:		2253447780

	MAIL ADDRESS:	
		STREET 1:		C/O ANDREEFF EQUITY ADVISORS LLC
		STREET 2:		450 LAUREL ST STE 2105
		CITY:			BATON ROUGE
		STATE:			LA
		ZIP:			70801
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>dane_andreef-form4ex.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2007-11-28</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0001103390</issuerCik>
        <issuerName>Ardea Biosciences, Inc./DE</issuerName>
        <issuerTradingSymbol>RDEA</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001201810</rptOwnerCik>
            <rptOwnerName>ANDREEFF DANE</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O ANDREEFF EQUITY ADVISORS,  L.L.C.</rptOwnerStreet1>
            <rptOwnerStreet2>450 LAUREL STREET, SUITE 2105</rptOwnerStreet2>
            <rptOwnerCity>BATON ROUGE</rptOwnerCity>
            <rptOwnerState>LA</rptOwnerState>
            <rptOwnerZipCode>70801</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2007-11-28</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>17000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>11.1618</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>1208202</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnote</value>
                    <footnoteId id="F1"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2007-11-30</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>1594</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>13.1988</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>1208202</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnote</value>
                    <footnoteId id="F1"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">This transaction was made by funds that are not, themselves, reporting persons.  Mr. Andreeff is reporting this transaction
 because (a) he is the managing member of one of the fund's general partner and thus may be deemed an indirect beneficial
 owner of that fund's holdings and (b) he is a director of the other fund and thus may be deemed an indirect beneficial owner
 of that fund's holdings.  Mr. Andreeff disclaims beneficial ownership of the reported securities except to the extent of his
 pecuniary interest therein.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Dane Andreeff</signatureName>
        <signatureDate>2007-12-05</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----