Collaborative Arrangements - Novartis (Details) - USD ($) $ in Thousands	3 Months Ended	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020	May 31, 2019
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Contract liabilities: deferred revenue	$ 30,609	$ 30,609	$ 6,335
Liability, revenue recognized		$ 1,500
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2023-01-01
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Expected timing of satisfaction, period	1 year	1 year
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2024-01-01
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Expected timing of satisfaction, period	1 year	1 year
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2025-01-01
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Expected timing of satisfaction, period	1 year	1 year
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2026-01-01
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Expected timing of satisfaction, period	1 year	1 year
Novartis
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Contract liabilities: deferred revenue					$ 5,000
Liability, revenue recognized		$ 1,000	1,600	$ 6,200
Novartis | Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2023-01-01
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Expected timing of satisfaction, period	23 months	23 months
Novartis | Computer equipment and software
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Contingent annual payments, term		4 years
Contingent annual receivable increase					$ 8,000
Revenue recognition, annual payment	$ 2,000
Novartis | Milestone One
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Contingent receivable				$ 4,000
Novartis | Milestone Two
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Contingent receivable			$ 5,000