Income Taxes - NOL Carryforwards and Federal Research and Development Tax Credits (Details) $ in Thousands	Dec. 31, 2021 USD ($)
Federal
Operating Loss and Tax Credit Carryforwards [Line Items]
Net operating losses, amount	$ 224,475
Net operating losses, not subject to expiration, amount	108,314
Tax credits, amount	12,917
State
Operating Loss and Tax Credit Carryforwards [Line Items]
Net operating losses, amount	138,770
Tax credits, amount	14,126
Foreign
Operating Loss and Tax Credit Carryforwards [Line Items]
Net operating losses, amount	$ 0