Collaborative Arrangements - Pfizer Purchase Orders (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Sales revenue, goods	$ 104,754	$ 69,056	$ 68,458
Pfizer | Enzyme Product
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Liability, revenue recognized	34,500
Sales revenue, goods	$ 1,700
Pfizer | Enzyme Product | Revenue from Contract with Customer Benchmark | Customer Concentration Risk
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Concentration risk, percentage	33.00%