Collaborative Arrangements - Novartis (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019	May 31, 2019
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Contract liabilities, deferred revenue	$ 6,335	$ 4,791
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2022-01-01
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Expected timing of satisfaction, period	1 year
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2023-01-01
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Expected timing of satisfaction, period	1 year
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2024-01-01
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Expected timing of satisfaction, period	1 year
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2025-01-01
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Expected timing of satisfaction, period
Novartis
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Contract liabilities, deferred revenue				$ 5,000
Liability, revenue recognized	$ 1,600	6,200	$ 11,300
Novartis | Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2022-01-01
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Expected timing of satisfaction, period	23 months
Novartis | Computer equipment and software
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Contingent annual payments, term	4 years
Contingent annual receivable increase				$ 8,000
Novartis | Milestone One
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Contingent receivable		$ 4,000
Novartis | Milestone Two
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Contingent receivable	$ 5,000