Commitments and Contingencies (Tables)

12 Months Ended

Dec. 31, 2021

Commitments and Contingencies Disclosure [Abstract]

Lease Cost

Lease costs, amounts included in measurement of lease obligations and other information related to non-cancellable operating leases and finance leases for the years ended December 31, 2021, 2020 and 2019 were as follows (in thousands):

	Year Ended December 31,
	2021		2020		2019
Amortization of right-of-use assets	$	106	$	152	$	217
Interest on lease obligations	—		1		10
Finance lease costs	106		153		227
Operating lease cost	4,396		3,879		4,556
Short-term lease costs (1)	70		47		—
Sublease income	—		(55)		(957)
Total lease cost (2)	$	4,572	$	4,024	$	3,826
(1) Short-term lease costs on leases with terms of over one month and less than one year.
(2) The Company had no variable lease costs.

Amounts included in measurement of lease obligations:

	Year Ended December 31,
	2021		2020			2019
Cash paid:
Operating cash flows from operating leases	$	4,197	$	2,816		$	3,279
Operating cash flow from finance leases	$	—	$	1		$	10
Financing cash flows from finance leases	$	—	$	60		$	242
Non-cash activity:
Operating Lease - Right-of-use assets obtained in exchange for lease liabilities	$	25,445	$	—		$	26,617
Finance Lease - Right-of-use assets obtained in exchange for lease liabilities	$	—	$	—		$	493
			Operating Lease			Finance Lease
Other information:
Weighted-average remaining lease term (in years)			7.9 years			—
Weighted-average discount rate			5.6		%	—

Operating Lease Maturity

As of December 31, 2021, our maturity analysis of annual undiscounted cash flows of the non-cancellable operating leases are as follows (in thousands):

Years ending December 31,	Operating Leases
2022	$	6,500
2023	7,571
2024	7,785
2025	8,007
2026	8,235
Thereafter	20,718
Total minimum lease payments	58,816
Less: imputed interest	11,162
Lease obligations	$	47,654

Schedule of Supply Commitment

The following table provides quantitative data regarding our other commitments. Future minimum payments reflect amounts that we expect to pay including potential obligations under services agreements subject to risk of cancellation by us (in thousands):

Other Commitment Agreement Type	Agreement Date	Future Minimum Payment
Manufacture and supply agreement with expected future payment date of December 2022	April 2016	$	101
Development and manufacturing services agreements	September 2019	2,469
Facility maintenance agreement	September 2021	1,475
Total other commitments		$	4,045