Amount of accumulated depreciation, depletion and amortization for physical assets used in the normal conduct of business to produce goods and services.

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The amount of expense recognized in the current period that reflects the allocation of the cost of tangible assets over the assets' useful lives. Includes production and non-production related depreciation.

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Amount before accumulated depreciation, depletion and amortization of physical assets used in the normal conduct of business and not intended for resale. Examples include, but are not limited to, land, buildings, machinery and equipment, office equipment, and furniture and fixtures.

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Balance Sheets Details - Property and Equipment, net (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2021	Jun. 30, 2020	Jun. 30, 2021	Jun. 30, 2020	Dec. 31, 2020
Property, Plant and Equipment [Line Items]
Property and equipment	$ 45,673		$ 45,673		$ 43,048
Less: accumulated depreciation and amortization	(34,441)		(34,441)		(33,373)
Property and equipment, net	11,232		11,232		9,675
Depreciation	716	$ 462	1,375	$ 900
Laboratory equipment
Property, Plant and Equipment [Line Items]
Property and equipment	28,623		28,623		25,468
Leasehold improvements
Property, Plant and Equipment [Line Items]
Property and equipment	10,785		10,785		10,785
Computer equipment and software
Property, Plant and Equipment [Line Items]
Property and equipment	3,283		3,283		3,192
Office equipment and furniture
Property, Plant and Equipment [Line Items]
Property and equipment	1,246		1,246		1,246
Construction in progress
Property, Plant and Equipment [Line Items]
Property and equipment	$ 1,736		$ 1,736		$ 2,357