Collaborative Arrangements - Merck Sitagliptin Catalyst Supply Agreement (Details) - USD ($)	1 Months Ended	3 Months Ended		6 Months Ended
	Dec. 31, 2015	Jun. 30, 2020	Jun. 30, 2019	Jun. 30, 2020	Jun. 30, 2019	Dec. 31, 2019
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Revenue recognized		$ 14,967,000	$ 12,319,000	$ 29,637,000	$ 27,901,000
Contract with customer, liability		5,045,000		5,045,000		$ 2,044,000
Supply Agreement [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Contract with customer, liability		2,000,000.0		2,000,000.0		2,000,000.0
Merck [Member] | Supply Agreement [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Optional extension period	5 years
Merck [Member] | Supply Agreement [Member] | Product Sales [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Revenue recognized		2,000,000.0	$ 2,500,000	3,800,000	$ 7,800,000
Contract with customer, liability		$ 300,000		$ 300,000		$ 0