Segment, Geographical and Other Revenue Information - Segment Reporting (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Segment Reporting Information [Line Items]
Total revenues	$ 60,594	$ 50,024	$ 48,837
Cost of product revenue	12,620	14,327	9,753
Research and development	29,978	29,659	22,229
Selling, general and administrative	29,291	29,008	25,419
Total costs and operating expenses	71,889	72,994	57,401
Loss from operations	(11,295)	(22,970)	(8,564)
Depreciation	(1,147)	(1,042)	(1,734)
Loss before income taxes	(10,915)	(22,915)	(8,598)
Share-based compensation	7,889	7,091	5,673
Operating Segments
Segment Reporting Information [Line Items]
Total revenues	60,594	50,024
Cost of product revenue	12,620	14,327
Research and development	29,109	28,954
Selling, general and administrative	8,309	7,371
Total costs and operating expenses	50,038	50,652
Loss from operations	10,556	(628)
Share-based compensation	2,929	2,514
Operating Segments | Performance Enzymes
Segment Reporting Information [Line Items]
Total revenues	47,073	42,333
Cost of product revenue	12,620	14,327
Research and development	18,924	16,847
Selling, general and administrative	7,538	7,371
Total costs and operating expenses	39,082	38,545
Loss from operations	7,991	3,788
Share-based compensation	2,591	2,306
Operating Segments | Novel Biotherapeutics
Segment Reporting Information [Line Items]
Total revenues	13,521	7,691
Cost of product revenue	0	0
Research and development	10,185	12,107
Selling, general and administrative	771	0
Total costs and operating expenses	10,956	12,107
Loss from operations	2,565	(4,416)
Share-based compensation	338	208
Corporate, Non-Segment
Segment Reporting Information [Line Items]
Total costs and operating expenses	(20,324)	(21,245)
Depreciation	1,147	1,042
Product Sales
Segment Reporting Information [Line Items]
Total revenues	25,590	26,685	$ 15,321
Product Sales | Operating Segments
Segment Reporting Information [Line Items]
Total revenues	25,590	26,685
Product Sales | Operating Segments | Performance Enzymes
Segment Reporting Information [Line Items]
Total revenues	25,590	26,685
Product Sales | Operating Segments | Novel Biotherapeutics
Segment Reporting Information [Line Items]
Total revenues	0	0
Research and Development Revenues
Segment Reporting Information [Line Items]
Total revenues	35,004	23,339
Research and Development Revenues | Operating Segments
Segment Reporting Information [Line Items]
Total revenues	35,004	23,339
Research and Development Revenues | Operating Segments | Performance Enzymes
Segment Reporting Information [Line Items]
Total revenues	21,483	15,648
Research and Development Revenues | Operating Segments | Novel Biotherapeutics
Segment Reporting Information [Line Items]
Total revenues	$ 13,521	$ 7,691