Basis of Presentation and Summary of Significant Accounting Policies - Narrative (Details)		12 Months Ended
	Jan. 01, 2018 USD ($)	Dec. 31, 2018 USD ($) segment	Dec. 31, 2017 USD ($) segment	Dec. 31, 2016 USD ($)	Feb. 28, 2019 USD ($)	Jan. 01, 2019 USD ($)
Restricted Cash and Cash Equivalents Items [Line Items]
Number of reportable segments | segment		2
Number of operating segments | segment		2	1
Advertising expense		$ 500,000	$ 700,000	$ 500,000
Cash and cash equivalents		53,039,000	31,219,000	19,240,000
Cash		21,800,000	24,400,000
Money market funds		31,200,000	6,800,000
Unbilled receivables, not billable		2,700,000
Impairment of long-lived assets held-for-use		0	0	0
Goodwill		3,241,000	3,241,000
Goodwill impairment		0	0	0
Provision for (benefit from) income taxes		(37,000)	81,000	$ (40,000)
Provisional income tax expense valuation		34,100,000
Cumulative effect of change in accounting principles		(4,059,000)
Accounting Standards Update 2014-09
Restricted Cash and Cash Equivalents Items [Line Items]
Cumulative effect of change on equity or net assets		4,100,000
Accounting Standards Update 2016-01
Restricted Cash and Cash Equivalents Items [Line Items]
Cumulative effect of change on equity or net assets		$ 500,000
Cumulative effect of change in accounting principles	$ 500,000
Reclassification from AOCI, current period, tax	$ 600,000
Performance Enzymes
Restricted Cash and Cash Equivalents Items [Line Items]
Goodwill, allocation percent		76.00%
Goodwill		$ 2,400,000
Novel Biotherapeutics
Restricted Cash and Cash Equivalents Items [Line Items]
Goodwill, allocation percent		24.00%
Goodwill		$ 800,000
Subsequent Event
Restricted Cash and Cash Equivalents Items [Line Items]
Operating lease, right-of-use asset						$ 20,000,000
Operating lease, liability						30,000,000
Finance lease, right-of-use asset						100,000
Finance lease, liability						$ 800,000
Eighth Lease Amendment | Subsequent Event
Restricted Cash and Cash Equivalents Items [Line Items]
Letters of credit					$ 1,100,000
Trustee Deposit
Restricted Cash and Cash Equivalents Items [Line Items]
Restricted cash and investments, noncurrent		700,000	800,000
Demand Deposits [Member]
Restricted Cash and Cash Equivalents Items [Line Items]
Restricted cash and investments, noncurrent			700,000
Letter of Credit | Demand Deposits [Member]
Restricted Cash and Cash Equivalents Items [Line Items]
Restricted cash and investments, noncurrent		$ 700,000	$ 800,000