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Segment, Geographical and Other Revenue Information - Segment Reporting (Details) $ in Thousands	3 Months Ended				12 Months Ended
	Mar. 31, 2018 operating_segment	Mar. 31, 2018 USD ($)	Mar. 31, 2018 segment	Mar. 31, 2017 USD ($)	Dec. 31, 2017 segment
Segment Reporting Information [Line Items]
Number of operating segments	2		2		1
Product revenue		$ 6,163		$ 5,586
Research and development revenue		7,879		2,385
Total revenues		14,042		7,971
Cost of product revenue		3,825		3,002
Research and development		7,178		5,839
Selling, general and administrative		7,746		6,606
Total costs and operating expenses		18,749		15,447
Income (loss) from operations		(4,707)		(7,476)
Income (Loss) before income taxes		(4,696)		(7,436)
Stock-based compensation		1,980		1,669
Operating Segments
Segment Reporting Information [Line Items]
Product revenue		6,163		5,586
Research and development revenue		7,879		2,385
Total revenues		14,042		7,971
Cost of product revenue		3,825		3,002
Research and development		6,998		5,661
Selling, general and administrative		2,242		1,812
Total costs and operating expenses		13,065		10,475
Income (loss) from operations		977		(2,504)
Stock-based compensation		396		273
Operating Segments \| Performance Enzymes
Segment Reporting Information [Line Items]
Product revenue		6,163		5,586
Research and development revenue		4,566		2,385
Total revenues		10,729		7,971
Cost of product revenue		3,825		3,002
Research and development		5,066		4,150
Selling, general and administrative		2,096		1,812
Total costs and operating expenses		10,987		8,964
Income (loss) from operations		(258)		(993)
Stock-based compensation		333		221
Operating Segments \| Novel Biothera-peutics
Segment Reporting Information [Line Items]
Product revenue		0		0
Research and development revenue		3,313		0
Total revenues		3,313		0
Cost of product revenue		0		0
Research and development		1,932		1,511
Selling, general and administrative		146		0
Total costs and operating expenses		2,078		1,511
Income (loss) from operations		1,235		(1,511)
Stock-based compensation		63		52
Corporate
Segment Reporting Information [Line Items]
Total costs and operating expenses		(5,435)		(4,606)
Depreciation and amortization		$ (238)		$ (326)