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The cumulative amount of the reporting entity's undistributed earnings or deficit.

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Amount, including tax collected from customer, of revenue from satisfaction of performance obligation by transferring promised good or service to customer. Tax collected from customer is tax assessed by governmental authority that is both imposed on and concurrent with specific revenue-producing transaction, including, but not limited to, sales, use, value-added and excise.

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Amount of revenue recognized from goods sold, services rendered, insurance premiums, or other activities that constitute an earning process. Includes, but is not limited to, investment and interest income before deduction of interest expense when recognized as a component of revenue, and sales and trading gain (loss).

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Revenue Recognition (Details) - USD ($) $ in Thousands	3 Months Ended
Revenue Recognition (Details) - USD ($) $ in Thousands	Mar. 31, 2018	Mar. 31, 2017	Dec. 31, 2017
Disaggregation of Revenue [Line Items]
Increase in accumulated deficit	$ 324,291		$ 315,065
Increase in revenues	14,042	$ 7,971
Disaggregation of Revenue [Abstract]
Revenue	14,042	7,971
Americas [Member]
Disaggregation of Revenue [Line Items]
Increase in revenues	3,597	1,788
Disaggregation of Revenue [Abstract]
Revenue	3,597	1,788
EMEA [Member]
Disaggregation of Revenue [Line Items]
Increase in revenues	4,992	3,208
Disaggregation of Revenue [Abstract]
Revenue	4,992	3,208
APAC [Member]
Disaggregation of Revenue [Line Items]
Increase in revenues	5,453	2,975
Disaggregation of Revenue [Abstract]
Revenue	5,453	2,975
Product Revenue [Member]
Disaggregation of Revenue [Abstract]
Revenue	6,163	5,586
Research and Development Revenue [Member]
Disaggregation of Revenue [Abstract]
Revenue	7,879	2,385
Effect of change - higher (lower) [Member] \| Accounting Standards Update 2014-09 [Member]
Disaggregation of Revenue [Line Items]
Increase in accumulated deficit	1,554		$ 4,100
Increase in revenues	3,837
Performance Enzymes
Disaggregation of Revenue [Abstract]
Revenue	10,729	7,971
Performance Enzymes \| Americas [Member]
Disaggregation of Revenue [Abstract]
Revenue	3,597	1,788
Performance Enzymes \| EMEA [Member]
Disaggregation of Revenue [Abstract]
Revenue	1,679	3,208
Performance Enzymes \| APAC [Member]
Disaggregation of Revenue [Abstract]
Revenue	5,453	2,975
Performance Enzymes \| Product Revenue [Member]
Disaggregation of Revenue [Abstract]
Revenue	6,163	5,586
Performance Enzymes \| Research and Development Revenue [Member]
Disaggregation of Revenue [Abstract]
Revenue	4,566	2,385
Novel Biotherapeutics
Disaggregation of Revenue [Abstract]
Revenue	3,313	0
Novel Biotherapeutics \| Americas [Member]
Disaggregation of Revenue [Abstract]
Revenue	0	0
Novel Biotherapeutics \| EMEA [Member]
Disaggregation of Revenue [Abstract]
Revenue	3,313	0
Novel Biotherapeutics \| APAC [Member]
Disaggregation of Revenue [Abstract]
Revenue	0	0
Novel Biotherapeutics \| Product Revenue [Member]
Disaggregation of Revenue [Abstract]
Revenue	0	0
Novel Biotherapeutics \| Research and Development Revenue [Member]
Disaggregation of Revenue [Abstract]
Revenue	$ 3,313	$ 0