Commitments and Contingencies (Tables)

12 Months Ended

Dec. 31, 2017

Schedule of future minimum payments under non-cancellable operating leases

Future minimum payments under non-cancellable capital and operating leases at December 31, 2017 are as follows (in thousands):



Years ending December 31,	Capital Leases			Operating Leases
2018	$	252		$	3,185
2019	252			3,280
2020	60			712
2021	—			490
2022	—			41
Total minimum lease payments ⁽¹⁾	564			$	7,708
Less: amount representing interest	(32		)
Present value of capital lease obligations	532
Less: current portion	(230		)
Long-term portion of capital leases	$	302


⁽¹⁾	Minimum payments have not been reduced by future minimum sublease rentals of $1.2 million to be received under non-cancellable subleases.

Schedule of future minimum lease payments for capital leases

Future minimum payments under non-cancellable capital and operating leases at December 31, 2017 are as follows (in thousands):



Years ending December 31,	Capital Leases			Operating Leases
2018	$	252		$	3,185
2019	252			3,280
2020	60			712
2021	—			490
2022	—			41
Total minimum lease payments ⁽¹⁾	564			$	7,708
Less: amount representing interest	(32		)
Present value of capital lease obligations	532
Less: current portion	(230		)
Long-term portion of capital leases	$	302


⁽¹⁾	Minimum payments have not been reduced by future minimum sublease rentals of $1.2 million to be received under non-cancellable subleases.

Schedule of supply commitment

The following table provides quantitative data regarding our other commitments. Future minimum payments reflect amounts that we expect to pay including potential obligations under services agreements subject to risk of cancellation by us (in thousands):



Other Commitment Agreement Type	Agreement Date		Future Minimum Payment
Manufacture and supply agreement with expected future payment date of December 2022	April 2016	$	1,693
Service agreement for the development of manufacturing process	April 2017		1,082
Service agreement for stability study	July 2017		398
Service agreement for clinical trial	December 2017		294
Total other commitments		$	3,467

Schedule of credit facility prepayment terms

Prepayments of Term Debt and early termination of the Revolving Line of Credit are subject to prepayment and final payment fees are as follows:



	Term Debt	Revolving Line of Credit
Through and including the first anniversary of the funding date of the first Term Debt drawn	2.0%
After the first anniversary of the funding date of the first Term Debt drawn and before the maturity date	1.0%
On the earliest to occur of the maturity date, the acceleration of Term Debt drawn or prepayment of Term Debt drawn	5.5%
Through and including the first anniversary of the closing date		3.0%
After the first anniversary of the closing date through and including the second anniversary of the closing date		2.0%
After the second anniversary of the closing date through and including the third anniversary of the closing date		1.0%