Commitments and Contingencies - Narrative (Details) $ in Thousands	1 Months Ended			12 Months Ended
	Dec. 31, 2016 USD ($) ft² building claim	Oct. 31, 2016 USD ($)	Apr. 30, 2016 USD ($)	Dec. 31, 2016 USD ($) ft² building claim	Dec. 31, 2015 USD ($)	Dec. 31, 2014 USD ($)
Long-term Purchase Commitment [Line Items]
Lease area space occupancy (in square feet) | ft²	107,200			107,200
Number of buildings | building	4			4
Incentive from Lessor	$ 1,300			$ 1,300	$ 1,700
Asset retirement obligations	400			400	400
Letters of credit	800			800	800
Remaining minimum lease payments	10,785			10,785
Rent expense				3,400	3,400	$ 3,400
Sublease income				1,200	600	$ 400
Total future minimum sublease rentals to be received under noncancellable subleases	1,800			$ 1,800
Capital lease obligations incurred	$ 500
Capital leases, term of contract	3 years
Number of claims pending | claim	5			5
Non-current portion of lease incentive obligation
Long-term Purchase Commitment [Line Items]
Incentive from Lessor	$ 900			$ 900	$ 1,300
Manufacture and Supply Agreement
Long-term Purchase Commitment [Line Items]
Commitment amount			$ 1,800
Research and development arrangement
Long-term Purchase Commitment [Line Items]
Commitment amount		$ 1,400
Notice to suppliers to cancel agreement		60 days